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Intracellular Ca2+ signalling; mitochondrial Ca2+ homeostasis and its role in aerobic metabolism; pathogenic mechanisms of mitochondrial diseases; functional analysis of Ca2+ transporting proteins in living cells, with a special attention to the plasma membrane Ca2+-ATPases; analysis of Ca2+ homeostasis in living cells carrying mutations in isoform 2 of the plasma membrane Ca2+-ATPase causing hearing loss and in isoform 3 causing cerebellar ataxia; analysis of Ca2+ homeostasis in cell model for neuromuscular and neurodegenerative diseases. Study of the Parkinson disease-related proteins (alpha-synuclein, DJ-1, parkin and PINK1) in cell signaling, calcium homeostasis, mitochondrial function and ER/mitochondria interactions. Development of recombinant tools based on splitGFP to monitor organelles contact sites and sub-mitochondrial distribution of proteins of interest.
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论文共 182 篇作者统计合作学者相似作者
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Nature communicationsno. 1 (2024): 1516-1516
Nature Communicationsno. 1 (2024)
Nature Communicationsno. 1 (2024): 1-20
Elena Poggio,Lucia Barazzuol,Andrea Salmaso, Celeste Milani, Adamantia Deligiannopoulou, Ángeles García Cazorla,Se Song Jang,Natalia Juliá-Palacios,Boris Keren,Robert Kopajtich,Sally Ann Lynch,Cyril Mignot,
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Cell Death & Diseaseno. 4 (2023): 1-13
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