RESEARCH INTEREST Intracellular Ca2+ signalling; mitochondrial Ca2+ homeostasis and its role in aerobic metabolism; pathogenic mechanisms of mitochondrial diseases; functional analysis of Ca2+ transporting proteins in living cells, with a special attention to the plasma membrane Ca2+-ATPases; analysis of Ca2+ homeostasis in living cells carrying mutations in isoform 2 of the plasma membrane Ca2+-ATPase causing hearing loss and in isoform 3 causing cerebellar ataxia; analysis of Ca2+ homeostasis in cell model for neuromuscular and neurodegenerative diseases. Study of the Parkinson disease-related proteins (alpha-synuclein, DJ-1, parkin and PINK1) in cell signaling, calcium homeostasis, mitochondrial function and ER/mitochondria interactions. Development of recombinant tools based on splitGFP to monitor organelles contact sites and sub-mitochondrial distribution of proteins of interest.