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The goal of Dr. Marian Young’s section is to explore the function of extracellular matrix (ECM) proteins found in skeletal tissues. The current focus is on the small leucine-rich proteoglycans (SLRPs) biglycan (bgn), decorin (dcn), and fibromodulin (fmod), and the Wnt target gene known as WISP1. Dr. Young’s research explores how these ECM components control skeletal tissue function via both anabolic (through differentiation and formation) and catabolic (breakdown or resorption) mechanisms which, in some cases, work by modulating growth factor availability. The group also investigates how stem cell fate can be regulated by the ECM in multiple skeletal sites including bones, teeth, cartilage and tendon. The ultimate purpose of the research is to develop practical applications for these ECM components in ameliorating diseases such as osteopenia (low bone mass), osteoarthritis (loss of cartilage) and ectopic bone formation in soft tissues.
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论文共 260 篇作者统计合作学者相似作者
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Yu Ishimoto,Luis F Menezes, Fang Zhou,Teruhiko Yoshida,Taishi Komori,Jiahe Qiu,Marian F Young,Huiyan Lu, Svetlana Potapova,Patricia Outeda,Terry Watnick,Gregory G Germino
Kidney international (2023)
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KIDNEY INTERNATIONALno. 3 (2023): 611-616
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