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A complex cross talk between tumor cells and the tumor microenvironment, comprising tumor-infiltrating lymphocytes, dictates the clinical outcome in neoplastic diseases. The unit is interested in defining cells and molecules relevant in the differentiation of CD4+ T lymphocyte subsets with anti-tumor or tumor-promoting function. The information derived by these studies will help in the design of clinical protocols of immune- biotherapy in neoplastic patients.
Group studies are focused on pancreatic cancer and multiple myeloma and they are conducted in collaboration with surgeons, clinical oncologists and pathologists of the Institute. In particular, specific aims are:
evaluating tumor infiltrating Th cell subsets and defining possible correlation between the features of the Th subsets identified and the clinical outcome (i.e., predictive markers);
studying cells and mechanisms dictating Th polarization;
studying how the different Th cell subsets exert pro- versus anti-tumor activity in these pathologies.
Group studies are focused on pancreatic cancer and multiple myeloma and they are conducted in collaboration with surgeons, clinical oncologists and pathologists of the Institute. In particular, specific aims are:
evaluating tumor infiltrating Th cell subsets and defining possible correlation between the features of the Th subsets identified and the clinical outcome (i.e., predictive markers);
studying cells and mechanisms dictating Th polarization;
studying how the different Th cell subsets exert pro- versus anti-tumor activity in these pathologies.
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论文共 125 篇作者统计合作学者相似作者
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Martina Spiga,Alessia Potenza, Stefano Beretta, Alessia Airaghi, Chiara Iozzi, Martina Fiumara, Samuele Ferrari, Neda Mohammadi, Oronza Botrugno, Maximilian Reichert,Maria Pia Protti, Stefano Crippa,
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Teresa Manzo, Tabea Sturmheit,Veronica Basso, Elisabetta Petrozziello,Rodrigo Hess Michelini,Michela Riba,Massimo Freschi, Angela R. Elia,Matteo Grioni,Flavio Curnis,Maria Pia Protti,Ton N. Schumacher,
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Teresa Manzo, Tabea Sturmheit,Veronica Basso, Elisabetta Petrozziello,Rodrigo Hess Michelini,Michela Riba,Massimo Freschi, Angela R. Elia,Matteo Grioni,Flavio Curnis,Maria Pia Protti,Ton N. Schumacher,
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Lucia De Monte,Francesca Clemente,Eliana Ruggiero, Raffaella Pini, Maria Grazia Ceraolo,Marco Schiavo Lena,Chiara Balestrieri,Dejan Lazarevic, Giulio Belfiori,Stefano Crippa,Gianpaolo Balzano,Massimo Falconi,
EBioMedicine (2023): 104819-104819
Teresa Manzo, Tabea Sturmheit,Veronica Basso, Elisabetta Petrozziello,Rodrigo Hess Michelini,Michela Riba,Massimo Freschi, Angela R. Elia,Matteo Grioni,Flavio Curnis,Maria Pia Protti,Ton N. Schumacher,
crossref(2023)
Teresa Manzo, Tabea Sturmheit,Veronica Basso, Elisabetta Petrozziello,Rodrigo Hess Michelini,Michela Riba,Massimo Freschi, Angela R. Elia,Matteo Grioni,Flavio Curnis,Maria Pia Protti,Ton N. Schumacher,
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