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个人简介
With a focus on biomedical sciences, my research interests lie within the fields of cellular and molecular biology of cancers and human stem cells. My expertise is in the molecular mechanisms underlying inflammatory-induced carcinogenesis and aneuploidy mechanisms in human-induced pluripotent stem cells and various types of cancers.
Throughout my academic career, as a graduate student, I have been dedicated to exploring the chemopreventive and chemotherapeutic properties of novel anti-cancer drug candidates and their influence on cancer-related signaling pathways. My overarching goal has been to conduct comprehensive and detailed evaluations of newly designed and synthesized compounds to identify the most promising candidates for in vivo studies. I gained my Doctor of Pharmacy (Pharm.D.) degree with a distinction award for evaluating therapeutic properties of novel oleanolic acid oximes derivatives on Nrf2 and STATs transcription factors in hepatocellular carcinoma.
I gained my Doctor of Philosophy (Ph.D.) degree in Medical and Health Sciences with distinction awards for investigating in vitro effects of novel oleanolic acid oximes derivatives (OAO) conjugated with non-steroidal anti-inflammatory drugs (NSAIDs) in the liver and pancreatic cancer cells, allowing the selection of potential anti-cancer and chemopreventive agents for preclinical studies.
As a Post-doctoral Fellow, my current research focuses on aneuploidy mechanisms in human induced pluripotent stem cells (iPSCs). Human iPSCs hold great potential in advancing our understanding of tumor development, progression, and treatment. In particular, the ability to generate patient-specific therapies using iPSCs promises sweeping advances in medicine, as it minimizes the risk of immune rejection. However, a major challenge with iPSCs is the extended period of cell culture required for their development and expansion, which often leads to genetic and epigenetic abnormalities that can confer cancer-like properties. The most common genetic abnormality observed in iPSCs is trisomy 12, which amplifies several known oncogenic and proliferation genes. My recent contributions to the field include the discovery of a novel mechanism for chromosome 12 trisomy acquisition in iPSCs, which could have profound implications for understanding genome instability leading to aneuploidies in human stem cells and cancer.
My current research aims to complete studies to map potentially novel molecular mechanisms for acquiring chromosome 12 trisomy and further interventions to prevent trisomy 12. Understanding the mechanisms underlying chromosome instability in iPSCs can enhance our understanding of chromosome instability in cancer and enable the development of strategies to prevent aneuploidy in iPSCs, improving the safety and efficacy of iPSC-based therapies.
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Cancer Researchno. 12_Supplement (2022): 106-106
Molecules (Basel, Switzerland)no. 24 (2022): 8779-8779
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