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The Li Ka Shing Faculty of Medicine of The University of Hong Kong (HKU) has conducted a whole genome sequencing study to decode the DNA changes in the entire genomes of HSCR patients. The study revealed that disease risk is determined by different constellations of multiple DNA changes. Importantly, using a human stem cell-based disease model, the team further demonstrated that genes implicated in Alzheimer’s disease pathway are dysregulated in a subgroup of HSCR patients, suggesting these two diseases may share some common pathological mechanisms and druggable targets. The research has just been published in Gastroenterology, the top journal in the field of Gastroenterology.
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论文共 106 篇作者统计合作学者相似作者
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Wai-Yee Lam,Clara Sze-Man Tang,Man-Ting So, Haibing Yue,Jacob Shujui Hsu,Patrick Ho-Yu Chung,John M. Nicholls,Fanny Yeung, Chun-Wai Davy Lee,Diem Ngoc Ngo,Pham Anh Hoa Nguyen,Hannah M. Mitchison,
Yujie Cao, Shau Yin Ha, Chi-Chiu So, Tong Ming For,Clara Sze-Man Tang,Huoru Zhang,Rui Liang,Jing Yang,Brian Hon-Yin Chung,Godfrey Chi-Fung Chan,Yu-Lung Lau,Maria‑Mercè Garcia‑Barcelo,
crossref(2021)
William W. Y. Lam, Masatomo So, Hsu Js, Chung Ph, Ngo Dn, Nguyen Pah,Hannah M. Mitchison,Dagan Jenkins,Christopher O’Callaghan,Pak C. Sham,María-Mercé García-Barceló, Lui Vc,
medRxiv (Cold Spring Harbor Laboratory) (2020)
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medrxiv(2020)
Laura E. Kuil,Katherine C. MacKenzie, Tang Cs,Jonathan D Windster, Le Tl,Anwarul Karim, de Graaf Bm,van der Helm R,van Bever Y, Sloots Ce,Conny Meeussen,Dick Tibboel,
medRxiv (Cold Spring Harbor Laboratory) (2020)
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