Maria Ciofani
副教授
Department of Molecular Genetics & Microbiology
Duke University School of Medicine;Department of Integrative Immunobiology, Duke University School of Medicine;Department of Cell Biology, Duke University School of Medicine;Duke Cancer Institute, Duke University School of Medicine
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IL-17-expressing CD4 T helper (Th17) cells are important members of the intestinal immune cell community that contribute to protection against bacterial and fungal infections, and maintenance of intestinal homeostasis. Although central to immunity, dysregulted Th17 cell function has been implicated in tissue inflammation and autoimmune disease (e.g. Inflammatory bowel disease, arthritis, and multiple sclerosis). In order to understand this balance between healthy and pathogenic responses, we are interested in defining the transcriptional regulatory mechanisms that govern (1) Th17 cell specification from naive T cell precursors and, (2) Th17 cell effector plasticity during inflammation. Combining genome-wide interrogation of regulatory information (transcription factor occupancy, chromatin accessibility, and transcriptional output) with gene-deficiency models in mice, we can dissect the contribution of key transcriptional regulators in proinflammatory T cell function.
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论文共 68 篇作者统计合作学者相似作者
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biorxiv(2024)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Science immunologyno. 88 (2023): eadg7597-eadg7597
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biorxiv(2022)
Matthew Gemberling,Keith Siklenka,Erica Rodriguez, Katherine R. Tonn-Eisinger,Alejandro Barrera, Fang Liu, Ariel Kantor, Liqing Li,Valentina Cigliola,Mariah F. Hazlett, Courtney Williams,Luke C. Bartelt,
bioRxiv (Cold Spring Harbor Laboratory) (2021)
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