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Vitamin D Regulation of the Immune System
The classic functions of vitamin D are in the regulation of bone remodeling and calcium homeostasis. The identification of vitamin D receptors in cells of the immune system sparked the early interest in vitamin D as an immune system regulator. Anecdotal data suggests a link between vitamin D status and the human autoimmune disease multiple sclerosis (MS). Experimentally, vitamin D deficiency exacerbates experimental autoimmune encephalomyelitis (EAE) an animal model of MS. Conversely, vitamin D supplementation prevents and ameliorates symptoms of EAE. The overall goal of the laboratory is to identify and characterize the cellular and molecular targets of vitamin D in the immune system and to therefore understand why vitamin D treatments are effective in EAE. In addition we are interested in identifying other diseases/conditions which might be affected by vitamin D status.
Nutritional control of host resistance to infection
Vitamin A and vitamin D regulate T cells. Experiments utilize an infection in mice that resembles human infections with enterophathogenic Escherica coli. Experiments determine the targets of vitamin A or vitamin D as regulators of the mucosal immune response to infection. Vitamin A deficient and vitamin D deficient mice are highly susceptible to infection of the gastrointestinal tract. In addition, the bacterial microbiota in the gut is regulated by vitamin A and vitamin D. Mechanisms to explain the effects of these nutrients on host resistance are the focus of this work.
Vitamin D status and inflammatory bowel disease
Inflammatory bowel diseases (IBDs) are immune mediated diseases of unknown etiology affecting the gastrointestinal tract. There are several factors, which suggest that vitamin D status and IBD are linked. The first is the geographical distribution of IBD. IBD is most prevalent in northern climates such as North America and Northern Europe . A major source of vitamin D is from its manufacture via a photolysis reaction in the skin and vitamin D synthesis from sunlight exposure is significantly less in northern climates. The second factor, which links vitamin D and IBD, is diet. Weight loss and vitamin D deficiency occurs in 65-75% of patients diagnosed with IBD. Whether vitamin D deficiency is a cause or an effect of IBD development is not known. We hypothesize and are presently in the process of determining whether vitamin D deficiency will exacerbate experimental IBD and whether supplementation with vitamin D will ameliorate symptoms of IBD.
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The Journal of steroid biochemistry and molecular biology (2023): 106253-106253
Juhi Arora,Devanshi R. Patel, McKayla J. Nicol,Cassandra J. Field, Katherine H. Restori,Jinpeng Wang, Nicole E. Froelich,Bhuvana Katkere,Josey A. Terwilliger,Veronika Weaver,Erin Luley,Kathleen Kelly,
Micha L. Davila,Ming Xu, Chengyu Huang,Erin R. Gaddes, Levi Winter,Margherita T. Cantorna,Yong Wang,Na Xiong
Juhi Arora,Devanshi Patel,McKayla J. Nicol,Cassandra J Field,Katherine H. Restori,Jinpeng Wang, Nicole E. Froelich,Bhuvana Katkere, Josey A. Terwilliger,Veronika Weaver, Erin Luley, Kathleen Kelly,
crossref(2022)
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