基本信息
浏览量:1
职业迁徙
个人简介
Margherita Bertuzzi is a molecular microbiologist specialising in fungal infection biology, whose research focuses on the antifungal phagocytic activities of the respiratory epithelium in health and disease.
With a major emphasis on pH-mediated signalling, her research has focused upon the way in which extracellular cues shape fungal tissue invasion and pathogenicity in mammalian hosts. During her PhD at Imperial College London (2007-2011), she developed the first, and only, protein-protein interaction toolkit for the major mould pathogen of human lungs Aspergillus fumigatus, demonstrating that a non-redundant pH sensor initiates pH signalling, which is critical for pathogenicity. This work [Bertuzzi & Bignell, Fungal Biology Reviews, 2011] has fuelled the exploration of fungal pH signalling as a drug target.
As a Postdoctoral Scientist at Imperial College London first (2011-2014) and then at the University of Manchester (2014-2017), she developed the first genetically-encoded biosensors of calcium signalling in A. fumigatus [Muñoz* & Bertuzzi*, et al., PloS one, 2015], which will facilitate discovery of new antifungal drugs. Furthermore, she demonstrated that A. fumigatus alkaline and calcium signalling, both critical for pathogenicity, have evolved to function independently, having important implications for antifungal drug discovery [Loss* & Bertuzzi*, et al., Molecular microbiology, 2017]. Also, she demonstrated that fungal invasion of the mammalian lung is genetically regulated [Bertuzzi*, et al., PLoS pathogens, 2014] and that uptake of fungal spores by the respiratory epithelium is one of the earliest events in the host-pathogen interaction.
As a Research Fellow at the University of Manchester (2017-2020) , she established novel single-cell approaches to demonstrate that phagocytic activities of cultured human airway epithelial cells directly and competently promote clearance of infecting fungal spores [methods chapters in Methods Handbook on Host-Fungal interactions, in press]. As an early career scientist developing an independent career in single cell technologies, she was awarded an MRC Discovery award from the University of Manchester (2017) to substantiate her results using clinical samples, thanks to an established collaboration between the Collaborative Centre for Inflammation Research (MCCIR), the Manchester University NHS Foundation Trust (Wythenshawe) and the National Aspergillosis Centre.
She was appointed Lecturer in Molecular Microbiology at the University of Manchester in 2020 to establish her research group, focusing on understanding epithelial encounters with inhaled respiratory pathogens and the role of these events in health and disease, especially in chronic obstructive pulmonary disease (COPD), a well-known risk factor for debilitating fungal lung disease. In the same year, she was also appointed Co-Director of the MRes Infection Biology programme, a novel research-focused 12-month full-time course (established in 18/19), which consolidates the interdisciplinary network of excellence in fundamental and clinical infectious diseases research at Manchester.
With a major emphasis on pH-mediated signalling, her research has focused upon the way in which extracellular cues shape fungal tissue invasion and pathogenicity in mammalian hosts. During her PhD at Imperial College London (2007-2011), she developed the first, and only, protein-protein interaction toolkit for the major mould pathogen of human lungs Aspergillus fumigatus, demonstrating that a non-redundant pH sensor initiates pH signalling, which is critical for pathogenicity. This work [Bertuzzi & Bignell, Fungal Biology Reviews, 2011] has fuelled the exploration of fungal pH signalling as a drug target.
As a Postdoctoral Scientist at Imperial College London first (2011-2014) and then at the University of Manchester (2014-2017), she developed the first genetically-encoded biosensors of calcium signalling in A. fumigatus [Muñoz* & Bertuzzi*, et al., PloS one, 2015], which will facilitate discovery of new antifungal drugs. Furthermore, she demonstrated that A. fumigatus alkaline and calcium signalling, both critical for pathogenicity, have evolved to function independently, having important implications for antifungal drug discovery [Loss* & Bertuzzi*, et al., Molecular microbiology, 2017]. Also, she demonstrated that fungal invasion of the mammalian lung is genetically regulated [Bertuzzi*, et al., PLoS pathogens, 2014] and that uptake of fungal spores by the respiratory epithelium is one of the earliest events in the host-pathogen interaction.
As a Research Fellow at the University of Manchester (2017-2020) , she established novel single-cell approaches to demonstrate that phagocytic activities of cultured human airway epithelial cells directly and competently promote clearance of infecting fungal spores [methods chapters in Methods Handbook on Host-Fungal interactions, in press]. As an early career scientist developing an independent career in single cell technologies, she was awarded an MRC Discovery award from the University of Manchester (2017) to substantiate her results using clinical samples, thanks to an established collaboration between the Collaborative Centre for Inflammation Research (MCCIR), the Manchester University NHS Foundation Trust (Wythenshawe) and the National Aspergillosis Centre.
She was appointed Lecturer in Molecular Microbiology at the University of Manchester in 2020 to establish her research group, focusing on understanding epithelial encounters with inhaled respiratory pathogens and the role of these events in health and disease, especially in chronic obstructive pulmonary disease (COPD), a well-known risk factor for debilitating fungal lung disease. In the same year, she was also appointed Co-Director of the MRes Infection Biology programme, a novel research-focused 12-month full-time course (established in 18/19), which consolidates the interdisciplinary network of excellence in fundamental and clinical infectious diseases research at Manchester.
研究兴趣
论文共 24 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Peter C Cook,Sheila L Brown,Emma Louise Houlder, Syed Baker,Freya R Svedberg,Gareth Howell,Margherita Bertuzzi, Louis Boon,Joanne E Konkel, Judith E Allen,Andrew S MacDonald
biorxiv(2024)
Sebastien C Ortiz,Rachael Fortune-Grant, Joshua Davies,Robin C May,Rebecca A Drummond,Margherita Bertuzzi
biorxiv(2023)
引用0浏览0引用
0
0
Margherita Bertuzzi,Gareth J Howell,Darren D Thomson,Rachael Fortune-Grant, Anna Moeslinger,Patrick Dancer,Norman Van Rhijn, Natasha Motsi, Xiaozhe Du, Alice Codling,Rajesh Shah, Mirac Demirbag,
biorxiv(2022)
Methods in Molecular BiologyHost-Fungal Interactionspp.83-109, (2021)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn