基本信息
浏览量:2
职业迁徙
个人简介
The major interest of my laboratory is the regulation of the development of the normal mammary gland. We are currently involved in three areas of investigation:
The regulation of lipid synthesis in the mammary gland. Here our focus is the mechanisms by which triglyceride is synthesized and secreted into milk. We are particularly interested in the role of the transcription factor SREBP-1 in regulating fatty acid synthesis and whether it plays a role in regulating lipid synthesis in breast cancer cells. We are using transgenic mice with defects in this pathway and dietary lipid to dissect molecular mechanisms of action.
Molecular mechanisms by which progesterone withdrawal activates milk secretion during the transition from pregnancy to lactation. We are currently using microarray analysis to identify candidate regulatory genes that coordinate the cellular response to progesterone withdrawal resulting in the secretion of copious quantities of milk. We have identified three candidate genes, IGFBP5, Wnt 5B and TGF-beta3 to mediate the progesterone response. We plan to use transgenic and KO mice mice to elucidate the mechanism by which these agents act.
Analysis of tight junction regulation in the mammary alveolar cell. We are currently defining the role of the claudins, transmembrane molecules thought to be important in cell-cell adhesion mediated at the tight junction, in the closure of tight junctions during the transition from pregnancy to lactation.
Since the pregnancy-lactation developmental cycle protects against breast cancer we believe the results of our studies are relevant both to the normal function of the mammary gland and its progression into breast cancer. Much of our work is carried out in animals, but cell culture models are also under study.
研究兴趣
论文共 112 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
The American journal of clinical nutrition (2023): S11-S27
引用12浏览0WOS引用
12
0
Animal frontiers : the review magazine of animal agricultureno. 3 (2023): 64-70
引用1浏览0WOS引用
1
0
Ion Transport Across Epithelial Tissues and DiseasePhysiology in Health and Diseasepp.177-239, (2020)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn