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Murine and human hematopoietic stem cells
Genetic and epigenetic regulation and development
Professional Statement
Murine and human hematopoietic stem cells; genetic and epigenetic regulation and development.
We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which control their behavior on a molecular level using genome-wide profiling strategies and mouse mutants.
研究兴趣
论文共 376 篇作者统计合作学者相似作者
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Linda Zhang,Joanne I. Hsu,Etienne D. Braekeleer,Chun-Wei Chen,Tajhal D. Patel, Alejandra G. Martell,Anna G. Guzman, Katharina Wohlan,Sarah M. Waldvogel, Hidetaka Urya,Ayala Tovy,Elsa Callen,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Linda Zhang,Joanne I Hsu, Etienne D Braekeleer,Chun-Wei Chen,Tajhal D Patel, Alejandra G Martell,Anna G Guzman, Katharina Wohlan,Sarah M Waldvogel, Hidetaka Urya,Ayala Tovy,Elsa Callen,
bioRxiv : the preprint server for biology (2024)
Nature reviews. Geneticspp.1-17, (2024)
Laure Maneix,Polina Iakova, Charles G Lee,Shannon E Moree, Xuan Lu,Gandhar K Datar, Cedric T Hill,Eric Spooner,Jordon C K King,David B Sykes, Borja Saez,Bruno Di Stefano,
Nature cell biologypp.1-11, (2024)
Chiraag D. Kapadia,Margaret A. Goodell
Nature Agingno. 3 (2024): 295-308
Chun-Wei Chen,Linda Zhang, Ravi Dutta,Abhishek Niroula,Peter G. Miller, Christopher J. Gibson, Alexander G. Bick,Jaime M. Reyes, Yi -Tang Lee,Ayala Tovy,Tianpeng Gu,Sarah Waldvogel,
Linda Zhang,Joanne I. Hsu, Etienne D. Braekeleer,Chun-Wei Chen,Tajhal D. Patel, Alejandra G. Martell,Anna G. Guzman,Katharina Wohlan,Sarah M. Waldvogel, Hidetaka Urya,Ayala Tovy,Elsa Callen,
crossref(2024)
Experimental Hematology (2023): S154
Chiraag D. Kapadia, Gerardo Rosas,Sachin G. Thakkar,Virginia Torrano, Jesse Wu,Tao Wang,Malcolm K. Brenner,Bambi J. Grilley,Helen E. Heslop,Margaret A. Goodell,Carlos A. Ramos,Premal D. Lulla
Transplantation and Cellular Therapyno. 2 (2023): S41-S42
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