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Marcy Zenobi-Wong’s main research focus is cartilage engineering and regeneration: the success of cell-based therapies for tissue repair is dependent on our ability to reliably control the growth and differentiation of stem cells used in the treatment.
The interaction of cells with the extracellular environment can have a potent influence on cell fate. The nature of biomaterials (composition, charge and stiffness), ligand and growth factor availability, oxygen tension and the presence of mechanical and electrical signals can potently induce the desired morphology, cytoskeletal architecture and biosynthetic activity. We engineer both 2D and 3D cellular systems to mimic different extracellular environments.
Using the layer-by-layer technique, nanofilms from natural and synthetic polymers can be used to coat biomedical devices, implants and tissue defects, where the terminal layer and stiffness of the nanofilm can be tuned to control the degree of cell adhesion and spreading.
We also use photolithography and printing techniques to pattern co-culture systems so that cell-cell and paracrine interactions can be studied. Other tools for developing functional mimics of the native 3D extracellular environment include the use of carbohydrate-based gels (methacrylated chondroitin sulfate, methacrylated hyaluronic acid, and sulfated alginate), incorporation of adhesion motives into gels and the use of mechanical loading to stimulate the development of engineered constructs.
This research lays the foundation for developing successful clinical strategies for tissue regeneration and repair.
The interaction of cells with the extracellular environment can have a potent influence on cell fate. The nature of biomaterials (composition, charge and stiffness), ligand and growth factor availability, oxygen tension and the presence of mechanical and electrical signals can potently induce the desired morphology, cytoskeletal architecture and biosynthetic activity. We engineer both 2D and 3D cellular systems to mimic different extracellular environments.
Using the layer-by-layer technique, nanofilms from natural and synthetic polymers can be used to coat biomedical devices, implants and tissue defects, where the terminal layer and stiffness of the nanofilm can be tuned to control the degree of cell adhesion and spreading.
We also use photolithography and printing techniques to pattern co-culture systems so that cell-cell and paracrine interactions can be studied. Other tools for developing functional mimics of the native 3D extracellular environment include the use of carbohydrate-based gels (methacrylated chondroitin sulfate, methacrylated hyaluronic acid, and sulfated alginate), incorporation of adhesion motives into gels and the use of mechanical loading to stimulate the development of engineered constructs.
This research lays the foundation for developing successful clinical strategies for tissue regeneration and repair.
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Kajetana Bevc,Lukas Malfertheiner, Kateryna Pantiukh,Madis Jaagura,Aki Havulinna,Veikko Salomaa,Elin Org,Christian von Mering,Marcy Zenobi Wong,Gonçalo Barreto
Osteoarthritis and Cartilage (2024): S60
Kajetana Bevc, Shipin Zhang, Junxuan Ma, Valentino Bruhin,Thomas Rauer, Matthias Steinwachs,Caroline Ospelt, Matteo D'Este, Christoph Pape,Kari Eklund,Gonçalo Barreto,Marcy Zenobi Wong
Osteoarthritis and Cartilage (2024): S386
ADVANCED FUNCTIONAL MATERIALSno. 6 (2024)
BIOFABRICATIONno. 2 (2024)
MRS COMMUNICATIONSno. 5 (2023): 764-785
Nature Reviews Methods Primersno. 1 (2023): 1-19
BIOFABRICATIONno. 3 (2023): 030401-030401
TISSUE ENGINEERING PART Ano. 11-12 (2023): 759-759
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