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Marcos Intaglietta joined UCSD in 1966 as a founding bioengineering faculty member. His pioneering work on artificial blood substitutes with Robert Winslow is now being developed through Sangart, a San Diego based company. He was the Chair of Sangart’s Scientific Advisory Board, and served on the company’s board of directors. Intaglietta received his Ph.D. in applied mechanics from the California Institute of Technology in 1963. He founded the International Institute for Microcirculation, and is an honorary member of the Italian, French, Indian, Argentinian and Mexican societies for microcirculation. Intaglietta received the Senior Scientist Award (1982) from the Humboldt Foundation, Germany, the Malpighi Gold Medal Award from the European Society for Microcirculation (1994), the Whitaker Award (1996), the Landis Award (1999) from the Microcirculation Society, the International Award (2002) from the Biomedical Engineering Society, the MD Degree honoris causa (2002) from the Ludwig-Maximilians-University Munich, Germany and the Asian Union for Microcirculation Award (2011).
Professor Intaglietta has largely influenced present understanding of the effects of viscosity and colloid osmotic pressure on the local regulation of blood flow and oxygen transport at the level of microscopic blood vessels. He is the author or co-author of more than 200 scientific papers and books and pioneered instruments currently in use in laboratories worldwide for studying the microcirculation. His fundamental discovery that oxygen is delivered in small pulses to the microcirculation has provided important information towards creating effective blood substitutes. Previously, substitutes actually caused blood vessels to constrict and shut down because the substitutes delivered too much oxygen. Intaglietta has also collaborated for many years with international colleagues in Europe, Latin America and Asia on projects related to blood plasma expanders for use in emergency situations and for companies with low blood bank supplies.
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Blood Substitutes and Oxygen Biotherapeuticspp.207-225, (2022)
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