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Signal transduction in the pancreatic β cell and regulation of insulin secretion. Glucose metabolism in the β cell triggers insulin secretion. The metabolic pathways involved in glucose-stimulated insulin secretion are still misunderstood. Our laboratory is working on the identification of the metabolic factors involved in coupling glucose metabolism and insulin secretion. We hypothesized that three metabolic cycles play a role in glucose-, fatty acid- and amino-acid-stimulated insulin secretion: the Krebs cycle, the pyruvate cycle and the glycerolipids/fatty acids cycle. With the help of a biochemical approach and molecular biology techniques such as the RNAi technology, adenovirus and KO mice, we are currently testing this hypothesis by overexpression or downregulation of key enzymes involved in intermediate metabolism regulation. We are also interested in the identification of genetic or nutritional defects (ex. excess of fatty acids) responsible for the aberrant insulin secretion in type 2 diabetes.
Signal transduction in the pancreatic β cell and regulation of insulin secretion. Glucose metabolism in the β cell triggers insulin secretion. The metabolic pathways involved in glucose-stimulated insulin secretion are still misunderstood. Our laboratory is working on the identification of the metabolic factors involved in coupling glucose metabolism and insulin secretion. We hypothesized that three metabolic cycles play a role in glucose-, fatty acid- and amino-acid-stimulated insulin secretion: the Krebs cycle, the pyruvate cycle and the glycerolipids/fatty acids cycle. With the help of a biochemical approach and molecular biology techniques such as the RNAi technology, adenovirus and KO mice, we are currently testing this hypothesis by overexpression or downregulation of key enzymes involved in intermediate metabolism regulation. We are also interested in the identification of genetic or nutritional defects (ex. excess of fatty acids) responsible for the aberrant insulin secretion in type 2 diabetes.
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDSno. 3 (2024): 159461-159461
Tianshu Xu,Jiyuan Yin,Xuan Dai,Tianyuan Liu,Hanfen Shi,Yueyi Zhang, Shan Wang, Gaiyue Yue,Yanfei Zhang,Dandan Zhao,Sihua Gao,Marc Prentki,
Phytomedicine (2024): 155375-155375
P. Pourshari, C. Schmitt, I. Chenier, Y. H. Leung, A. K. Oppong, Y. Bai,L. -L. Klein,A. Al-Mass,R. Lussier,M. Abu-Farha,J. Abubaker,F. Al-Mulla,
Molecular metabolism (2023): 101822-101822
DIABETESno. Supplement_1 (2023)
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Elite Possik, Laura-Lee Klein, Perla Sanjab,Ruyuan Zhu,Laurence Côté,Ying Bai,Dongwei Zhang, Howard Sun,Anfal Al-Mass,Abel Oppong,Rasheed Ahmad,Alex Parker,
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