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However, his interests were not confined to postsynaptic mechanisms. Marc’s work also addressed many other key features of biogenic amine neurotransmission, and always with a view towards developing therapies for major brain and behavioral disorders. With the cloning and characterization of the dopamine transporter, his group illuminated the mechanisms by which it regulates behavior through elegant studies with knockout mice. These studies not only demonstrated dramatic changes in dopamine-mediated behaviors in the absence of the carrier, but also revealed remarkable adaptive changes in the expression of receptors, enzymes and signaling molecules as the system strains to cope with sustained elevation of extracellular dopamine.
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Neuropharmacology (2023): 109544-109544
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Proceedings of the National Academy of Sciences of the United States of Americano. 10 (2022)
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