基本信息
浏览量:93
职业迁徙
个人简介
Research Interests
Structure and chemistry of bone mineral and matrix
Bone is heterogeneous, contains local areas which have just mineralized next to local areas which have been mineralized for longer periods of time. This heterogeneity renders analysis of whole bone misleading. We use the density fractionation technique to produce mineralization profiles in which newly-formed bone (low density fractions) can be separated from more mature bone, and we analyze the mineral and matrix m each fraction. In addition to chemical analyses we are using electron microscopy, X-ray and electron diffraction, neutron activation analysis and HPLC techniques. By studying the mineral-matrix interactions of the extracellular matrix of bone we are trying to understand the regulation of bone formation, mineralization and resorption.
Changes in Bone Mineral and Matrix with Age and Diseases
Mineralization profiles are a much more sensitive index of bone tissue age than the age of the animal. In normal physiological conditions there is a shift in the profile towards higher densities with aging. In pathological conditions either localized as in osteoarthritis or generalized as in osteoporosis subtle differences can be detected in the mineralization of the bone, confirming the view that in osteoporosis the nature of the bone changes as well as its quantity. We are correlating changes in bone tissue chemistry and architecture to bone mechanical strength.
Effects of Trace Elements and Drugs on Bone
It is possible to manipulate bones in to change their mineralization profile and therefore change their solubility and other material properties. We have shown that a high fluoride diet shifts bone mineralization profiles in rats as well as reducing bone solubility. We are also studying the affect of stable strontium on bone because strontium increases bone mass. In bisphosphonate treated animals we are studying the long term effects of lack of resorption on bone metabolism in animal models of arthritis and osteoporosis.
研究兴趣
论文共 409 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Connective tissue researchno. 4 (2023): 350-361
JBMR PLUSno. 12 (2023): e10841-e10841
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 104-104
引用0浏览0引用
0
0
AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY (2023): 16-16
引用0浏览0引用
0
0
The Journal of endocrinologyno. 1 (2022): 13-26
Adele Changoor, R Peter Suderman, Ibrahim Alshaygy, Ariel Fuhrmann,Margarete K. Akens,Oleg Safir,Marc D. Grynpas,Paul Kuzyk
Orthopaedic Proceedings (2021)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn