Dr Marc Aurel Busche’s research group studies brain ageing and dementia with a focus on the cellular and neural circuit mechanisms of Alzheimer’s Disease (AD), the most common cause of dementia in elderly people. Marc was among the first to employ high-resolution multiphoton imaging to reveal the earliest functional cellular changes in the amyloid beta plaque (Aβ)-bearing brain in vivo, and he identified a key role for abnormal neuronal hyperexcitability in AD that has inspired a number of ongoing clinical trials. Ongoing work in his laboratory employs advanced imaging, electrophysiological and analytical approaches to characterise the mechanisms underlying progressive cellular and circuit deterioration in AD, with the aim of identifying novel preventative and therapeutic targets. His work has earned him several accolades, including a prestigious Future Leaders Fellowship from UKRI. In addition to his commitment to research, he is an honorary consultant psychiatrist at Queen Square National Hospital for Neurology and Neurosurgery and sees patients approximately once a week.