基本信息
浏览量:2
职业迁徙
个人简介
Maor Sauler has been a member of the Pulmonary & Critical Care faculty since 2014. Dr. Sauler specializes in adult critical care including acute lung injury and sepsis. He also sees patients in the outpatient setting with pulmonary diseases such as Chronic Obstructive Pulmonary Disease (COPD). Dr. Sauler is board-certified in internal medicine, pulmonary medicine, and critical care medicine.
Dr. Sauler earned his undergraduate degree from Princeton University and received his MD from Rutgers-New Jersey Medical School. Dr. Sauler then completed both an internship and residency in internal medicine at Yale-New Haven Hospital. He went on to complete fellowship training in pulmonary and critical care medicine at Yale-School of Medicine.
The overall goal of Dr. Sauler's research program is to study biologic mechanisms that maintain lung "resilience" in response to oxidative stress and DNA damage. His research focuses on understanding cellular stress responses that change with age or with COPD, and then try to identify mechanisms through which these aberrant cellular stress responses contribute to susceptibility to injury, excessive inflammation, or abnormal lung repair. To do this, his lab integrates lung- and cell-targeted genetic mouse models, cell-based assays, novel imaging techniques, and multiple high-throughput genomic approaches. His work has focused on the role of Macrophage Migration Inhibitory Factor (MIF), a canonical innate immune cytokine that is secreted in response to oxidative stress, DNA damage, and infection. Dr. Sauler's lab has identified mechanisms through which this cytokine can mitigate oxidative stress, cellular senescence, and apoptosis, and promote tissue repair. His research has also demonstrated that expression of DNA repair enzymes are decreased in COPD and he has identified a dysregulated miR-24-3p/BRCA1 signaling network that may contribute to COPD pathogenesis.
Dr. Sauler earned his undergraduate degree from Princeton University and received his MD from Rutgers-New Jersey Medical School. Dr. Sauler then completed both an internship and residency in internal medicine at Yale-New Haven Hospital. He went on to complete fellowship training in pulmonary and critical care medicine at Yale-School of Medicine.
The overall goal of Dr. Sauler's research program is to study biologic mechanisms that maintain lung "resilience" in response to oxidative stress and DNA damage. His research focuses on understanding cellular stress responses that change with age or with COPD, and then try to identify mechanisms through which these aberrant cellular stress responses contribute to susceptibility to injury, excessive inflammation, or abnormal lung repair. To do this, his lab integrates lung- and cell-targeted genetic mouse models, cell-based assays, novel imaging techniques, and multiple high-throughput genomic approaches. His work has focused on the role of Macrophage Migration Inhibitory Factor (MIF), a canonical innate immune cytokine that is secreted in response to oxidative stress, DNA damage, and infection. Dr. Sauler's lab has identified mechanisms through which this cytokine can mitigate oxidative stress, cellular senescence, and apoptosis, and promote tissue repair. His research has also demonstrated that expression of DNA repair enzymes are decreased in COPD and he has identified a dysregulated miR-24-3p/BRCA1 signaling network that may contribute to COPD pathogenesis.
研究兴趣
论文共 110 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Maurizio Chioccioli, Shuyu Liu, Sumner Magruder,Aleksandra Tata, Lucia Borriello,John E McDonough,Arvind Konkimalla,Sang-Hun Kim,Jessica Nouws,David G Gonzalez,Brian Traub,Xianjun Ye,
Developmental cellno. 7 (2024): 830-840.e4
A. Korde, A. Ramaswamy,S. Anderson, B. Hu, W. Velasco Torrez, M. A. Pisani, J. Puchalski, D. Boffa,M. Sauler,S. Moghaddam, S. Takyar
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
引用0浏览0引用
0
0
J. Flint, P. Sharma,T. Adams, A. Lepe,H. Kim, N. Abu Hussein,J. C. Schupp, C. Cosme,J. E. Mcdonough,M. Sauler,X. Yan, N. Kaminski
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
引用0浏览0引用
0
0
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINEno. 9 (2023): 1114-1115
引用0浏览0引用
0
0
user-60ab1d9b4c775e04970067d6(2023)
J. Flint, P. Sharma, C. Cosme, N. Neumark,T. Adams,H. Kim, A. Lepe, N. Abu Hussein,J. C. Schupp,J. E. Mcdonough,M. Sauler,X. Yan,
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn