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职业迁徙
个人简介
For his postdoctoral work, he joined Prof. Tom Muir’s lab in Princeton where he developed and applied chemical biology tools to study chromatin modifying enzymes.
Research Interests
Proteins are controlled by a multitude of (bio-)chemically distinct post-translational modifications. Most research in this area focuses on modifications of amino acid side-chains, but emerging evidence suggests that alterations of the polypeptide backbone can similarly control protein structure and function. The Müller lab uses a chemical biology approach to reveal when, where and how protein backbone modifications contribute to biological regulation. Foremost, we employ protein semi-synthesis to install known protein backbone modifications, allowing us to directly measure their structural and functional consequences. In parallel, we aim to develop novel proteomics platforms to uncover previously uncharacterized protein backbone modifications.
Research Interests
Proteins are controlled by a multitude of (bio-)chemically distinct post-translational modifications. Most research in this area focuses on modifications of amino acid side-chains, but emerging evidence suggests that alterations of the polypeptide backbone can similarly control protein structure and function. The Müller lab uses a chemical biology approach to reveal when, where and how protein backbone modifications contribute to biological regulation. Foremost, we employ protein semi-synthesis to install known protein backbone modifications, allowing us to directly measure their structural and functional consequences. In parallel, we aim to develop novel proteomics platforms to uncover previously uncharacterized protein backbone modifications.
研究兴趣
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Chemical Science (2023)
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONno. 36 (2023): e202305326-e202305326
Biophysical Journalno. 3 (2022): 1a-1a
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