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个人简介
Dr. Brenner's primary research interest is the use of gene transfer to augment the immune response to human tumors, using vaccines and adoptive transfer of genetically modified T cells.
In neuroblastoma, Dr. Brenner and co-investigators have shown that T cells expressing a chimeric antigen receptor (CAR) for a surface marker (GD2) on neuroblastoma cells can produce tumor responses in more than half the patients with refractory or relapsed disease leading to complete remission in 3/11 patients. His Center is also studying the benefits of T cells modified with CARs directed to other tumor antigens on hematological malignancies and solid tumors including Hodgkin Disease and Glioblastoma multiforme and initial clinical results are promising. Efforts are being made to further increase the effectiveness of these CAR-T cells by incorporating genes that enhance T cell growth and survival and that render the T cells resistant to the inhibitory effects of many human tumors.
研究兴趣
论文共 926 篇作者统计合作学者相似作者
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LaQuisa C Hill,Rayne H Rouce, Mengfen J Wu,Tao Wang,Royce Ma, Huimin Zhang,Birju Mehta,Natalia Lapteva,Zhuyong Mei,Tyler S Smith,Lina Yang,Madhuwanti Srinivasan,
Bloodno. 13 (2024): 1231-1241
Andras Heczey,David Steffin,Nisha Ghatwai,Antonino Montalbano,Purva Rathi,Amy Courtney, Azlann Arnett,Julien Fleurence, Ramy Sweidan,Tao Wang, Huimin Zhang,Prakash Masand,
Research square (2024)
The Lancet. Oncologyno. 4 (2024): 488-500
Benjamin L Musher,Eric K Rowinsky,Brandon G Smaglo,Wasif Abidi,Mohamed Othman,Kalpesh Patel,Salmaan Jawaid, James Jing, Amanda Brisco,Ann M Leen,Mengfen Wu, Linda C Sandin,
The Lancet Oncologyno. 4 (2024): 488-500
Transplantation and Cellular Therapyno. 2 (2024): S41-S42
Cytotherapy (2024)
Helen Heslop, Che-Hsing Li,Sandhya Sharma,Andras Heczey,David Steffin,Chrystal Louis,Bambi Grilley,Sachin Thakkar,Meng-Fen Wu,Tao Wang,Cliona Rooney,Malcolm Brenner
Research square (2024)
Benjamin L Musher,Eric K Rowinsky, Brandon G Smaglo,Wasif Abidi,Mohamed Othman,Kalpesh Patel,Salmaan Jawaid, James Jing, Amanda Brisco,Ann M Leen,Mengfen Wu, Linda C Sandin,
The Lancet Oncologyno. 4 (2024): 488-500
Nature cancerpp.1-15, (2024)
openalex(2023)
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