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It is difficult to realize how little was known about γ-aminobutyric acid receptors when Raj began his studies of these receptors, and how much his work has changed the field. He published a paper in 1980 titled ‘The effects of acute and chronic ethanol administration and its withdrawal on gamma-aminobutyric acid receptor binding in rat brain’, which presaged the next decades of alcohol research. A particularly seminal contribution was the 1981 paper on ‘Histidine modification with diethyl pyrocarbonate shows heterogeneity of benzodiazepine receptors’. This work amazingly predicted what receptor cloning and sequencing would require another decade to reveal, that the α-subunits of the γ-aminobutyric acid-A receptor vary in a critical histidine that determines their drug sensitivity. He remained on the leading edge of investigations into N-methyl-D-aspartic acid and γ-aminobutyric acid-A receptor expression, trafficking, and phosphorylation, with important recent contributions in all these areas.
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Neurochemical Researchno. 2 (2008): 342-350
Brain research (2007): 47-52
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