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Dr. Madeleine Sharp is a neurologist specializing in movements disorders. Her research focuses on understanding the cognitive mechanisms that underlie cognitive dysfunction in patients with movement disorders. Movement disorders that affect the basal ganglia, such as Parkinson’s and Huntington’s disease, are increasingly recognized as impairing much more than movement. Cognitive and behavioral symptoms are very common in these patients but remain poorly understood and difficult to treat. Her lab’s research aims to relate what we know about the role of the basal ganglia in healthy cognition to patients’ common cognitive symptoms such as executive dysfunction, difficulty in multi-tasking and apathy. Examples of current projects include examining the role of the basal ganglia in orienting learning and memory towards motivationally significant goals, and examining the role of disturbed sleep in long-term memory in Parkinson’s patients. Her research combines behavioral experiments, pharmacological manipulations and neuroimaging in patients and healthy populations. Ultimately, the goal is to develop more precise models of cognitive dysfunction in patients, grounded in neurobiology, in order to develop and to reliably test novel behavioral and pharmacologic therapies.
研究兴趣
论文共 43 篇作者统计合作学者相似作者
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Andrzej Sokolowski,Nikhil Bhagwat,Yohan Chatelain,Mathieu Dugre,Alexandru Hanganu,Oury Monchi, Brent McPherson,Michelle Wang,Jean-Baptiste Poline,Madeleine Sharp,Tristan Glatard
PLOS ONEno. 1 (2024): e0295069-e0295069
Elodie Germani, Nikhil Baghwat,Mathieu Dugré,Rémi Gau,Albert Montillo,Kevin Nguyen, Andrzej Sokolowski,Madeleine Sharp,Jean-Baptiste Poline,Tristan Glatard
arxiv(2024)
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Nancy E. Mayo,Kedar K.V. Mate,Lesley K Fellows,Jose Morais,Madeleine Sharp, Anne-Lousie Lafontaine, Edward Hill,Ahmed Abou-Sharkh
crossref(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2024)
bioRxiv (Cold Spring Harbor Laboratory)no. 1 (2024): e0295069-e0295069
Clotilde Degroot, Kirsten Taylor,Vincent Mooser,Guy Rouleau,Ziv Gan-Or,Madeleine Sharp,Thomas Durcan,Ronald Postuma,Julien Doyon, Thomas Kustermann, Ravi Jagasia, Caitlin Taylor,
Journal of the Neurological Sciences (2023): 121747
Mohanad Arafe,Nikhil Bhagwat,Yohan Chatelain,Mathieu Dugré, Andrzej Sokołowski,Michelle Wang,Yiming Xiao,Madeleine Sharp,Jean‐Baptiste Poline,Tristan Glatard
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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medRxiv (Cold Spring Harbor Laboratory) (2022)
The Journal of Nuclear Medicineno. 3 (2022): 452-459
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