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He was also more actively involved in mass spectrometry. In conjunction with the chromatography methods he had co-developed, mass spectrometry began to give a unique insight into how specific lipids contribute to pathways, demonstrating that there is more than just the lipid head group in determining the role of a given lipid. With Robin Irvine of the University of Cambridge and colleagues, the Wakelam group investigated the processes that regulate cell adhesion. For those of us with long memories this was still largely a mystery to the scientific community (and is still not fully understood). Using a combination of GFP-tagged proteins, mass spectrometry of lipids, RNAi knockdown of enzymes and some inventive enzymology they demonstrated that phospholipase D2-derived phosphatidic acid regulates integrin-mediated adhesion through the generation of phosphatidylinositol 4,5-bisphosphate (Powner et al. 2005).
Michael was also a champion of lipid classification and tools for lipid identification, becoming a principle investigator on the LipidMaps consortium when the Wellcome Trust took over funding the tools and resources produced by the consortium. As part of this work he took part in updating the LipidMaps classification of lipids when these were expanded from a predominantly mammalian focused description to include lipids from plants and microbes, classifying a rich array of polyketides, sterols and isoprene compounds found across life (Fahy et al. 2008). In 2018 he was awarded the Moreton Lecture for his outstanding contributions to lipid biochemistry by the Biochemical Society.
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论文共 273 篇作者统计合作学者相似作者
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Rapid Communications in Mass Spectrometry (2023)
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Anna Kilbey, Anne Terry, Alma Jenkins,Gillian Borland,Qifeng Zhang,Michael J.O. Wakelam,Ewan R. Cameron,James C. Neil
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CELLSno. 20 (2022)
Zenodo (CERN European Organization for Nuclear Research) (2021)
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