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My current research concentrates on two main areas. The first is to address the molecular mechanism of the nuclear export of mRNA that does not employ karyopherin-family transport factors or Ran. I am concentrating on understanding the mechanism by which export-competent mRNPs are generated in the nucleus and how they are disassembled in the cytoplasm after passage through the pore. The second area is to investigate the role of nuclear trafficking components, the TREX-2 complex, and the polyA-binding protein, Nab2p, in orchestrating the gene expression machinery, especially in the context of their acting as scaffolds for the formation of the large macromolecular complexes involved in transcription, splicing, mRNA processing and nuclear export.
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Biographical Memoirs of Fellows of the Royal Society (2023): 345-360
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Jennifer Schanzle,Mililani Johnson Stewart,Fallon Lalor,Wilnadia Murrell,Lynn Matthews, Samantha Hill
The American Journal of the Medical Sciencesno. 3 (2023): S104-S105
Virusesno. 1 (2023): 33-33
Nature Communicationsno. 1 (2022)
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biorxiv(2021)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2021)
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