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个人简介
His scientific interests have formerly been focused on the study of the structure-function relationships of phosphomonohydrolases, notably acylphosphatases and low Mr phosphotyrosine protein phosphatases. He has formerly organized the laboratory of chemical synthesis of peptides at the Department of Biochemical Sciences of the University of Firenze. His efforts have been principally dedicated to the study of molecular biology issues such as protein folding, misfolding and aggregation of model proteins such as acylphosphatase, HypF-N, beta2 microglobulin Abeta peptides, amylin and prion proteins and to the investigation of the molecular mechanisms underlying amyloid aggregation and the cell biology of aggregate cytotoxicity on living systems. More recently, he focussed his research on the molecular and cellular basis of the protective effects of plant polyphenols, particularly oleuropein aglycone against amyloid diseases. The results of his researches have been reported in over 180 scientific papers published in outstanding international journals and widely cited (around 10000 total citations, over 6000 citations of the 10 most cited articles, ISI data), for an HI value of 46 (ISI). He has deposited three patents (Nr. MI2008A000514 of 27.03.08, PCT Nr. EP2009/053596 of 23/02/2011 and Nr. FI2011A000034 of 02/03/2011) for the use of oleuropein aglycone and its derivatives in the treatment of type II diabetes mellitus and Alzheimer’s disease.
研究兴趣
论文共 217 篇作者统计合作学者相似作者
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Ageing Research Reviews (2023): 101967-101967
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Cellsno. 18 (2023): 2258-2258
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Pharmaceuticals (Basel, Switzerland)no. 7 (2023): 933-933
PHARMACEUTICALSno. 3 (2022): 277-277
ANTIOXIDANTSno. 7 (2021): 1044
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