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We aim to decipher the ground rules of gene regulation and establish their functional interplay in biological phenomena involving global changes in phenotype, such as in cell differentiation and activation. Our current focus is on the role of non-coding DNA elements such as enhancers in integrating and transmitting gene regulatory information.
We combine experimental and computational approaches to study these questions, capitalising on our previous work on promoter-enhancer relationships, organisation of DNA regulatory elements and population genomics. Our particular interest is in human primary cells as models, and in genetic and epigenetic variation as “natural perturbations” in the system.
Our ultimate goal is to generate comprehensive functional models of gene control “logic” underlying cellular decisions. Interrogation and validation of these models will pinpoint key individual players (regulatory elements, genes, extrinsic signals) and their regulatory relationships in these processes and shed light on how they are remodelled in disease.
We combine experimental and computational approaches to study these questions, capitalising on our previous work on promoter-enhancer relationships, organisation of DNA regulatory elements and population genomics. Our particular interest is in human primary cells as models, and in genetic and epigenetic variation as “natural perturbations” in the system.
Our ultimate goal is to generate comprehensive functional models of gene control “logic” underlying cellular decisions. Interrogation and validation of these models will pinpoint key individual players (regulatory elements, genes, extrinsic signals) and their regulatory relationships in these processes and shed light on how they are remodelled in disease.
研究兴趣
论文共 69 篇作者统计合作学者相似作者
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Helen Ray-Jones, Zeji Song, Alexander Haglund, Pavel Artemov,Monica Della Rosa,Frances Burden,Roman Kreuzhuber, Anna Litovskikh, Vanessa Xue Hui Tan, Lai Ting Chan,Mattia Frontini,Chris Wallace,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Han Leng Ng,Mark E. Robinson, Valeria Malysheva, Ozgen Deniz,Nicholas Crump,Kadriye Nehir Cosgun, Kaiyue Helian,Mikhail Spivakov,Markus Muschen,Niklas Feldhahn
BLOOD (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Han Leng Ng,Mark E Robinson, Valeria Malysheva, Ozgen Deniz,Nicholas Crump,Kadriye Nehir Cosgun, Kaiyue Helian,Mikhail Spivakov,Markus Müschen,Niklas Feldhahn
Blood (2023): 2779
biorxiv(2022)
Matt D Worssam,Jordi Lambert,Sebnem Oc, James C K Taylor,Annabel L Taylor,Lina Dobnikar,Joel Chappell,Jennifer L Harman,Nichola L Figg,Alison Finigan,Kirsty Foote,Anna K Uryga,
Cardiovascular Researchno. 5 (2022): 1279-1294
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