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Our laboratory is interested in identifying, characterizing and determining the mechanisms of viral-induced immune disease in a variety of complex chronic disorders. These include, but are not limited to autoimmune diseases like diabetes, autoimmune myocarditis and multiple sclerosis, immunosuppression induced by viruses such as HIV and Measles, haemorrhagic fevers as observed following Dengue fever virus infection, and meningitis induced by viruses like West Nile Virus.
Specifically, the primary goal of our program is to interconnect the changes effecting the ability of the immune system to respond to infection with its ability to develop immune dysfunction leading to disease. Ongoing studies are aimed at describing and controlling the mechanisms of viral-induced autoimmune disease in at least two different mouse models. Both insulin-dependent Diabetes Mellitus and autoimmune myocarditis can be induced in mice and man by a common pathogen of childhood, coxsackievirus. Dependent on the strain of virus and the strain of mice, different outcomes of acute coxsackieviral infection can lead to the induction of chronic autoimmune diabetes, heart disease or no disease. Our laboratory has taken advantage of this model to study the specific components that regulate disease induction.
Specifically, the primary goal of our program is to interconnect the changes effecting the ability of the immune system to respond to infection with its ability to develop immune dysfunction leading to disease. Ongoing studies are aimed at describing and controlling the mechanisms of viral-induced autoimmune disease in at least two different mouse models. Both insulin-dependent Diabetes Mellitus and autoimmune myocarditis can be induced in mice and man by a common pathogen of childhood, coxsackievirus. Dependent on the strain of virus and the strain of mice, different outcomes of acute coxsackieviral infection can lead to the induction of chronic autoimmune diabetes, heart disease or no disease. Our laboratory has taken advantage of this model to study the specific components that regulate disease induction.
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Frontiers in Immunology (2024): 1361884-1361884
Jessica R. Allanach,Naomi M. Fettig, Blair K. Hardman, Vina Fan, Ariel R. Rosen,Erin J. Goldberg, Zachary J. Morse,Iryna Shanina,Galina Vorobeychik,Lisa C. Osborne,Marc S. Horwitz
crossref(2022)
biorxiv(2022)
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