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Although transcription factors and transcriptional regulation play key roles in circadian rhythmicity, post-transcriptional regulation has also received prominent attention. This is due to the potent effect of kinase mutants on Drosophila and mammalian timekeeping as well as some remarkable results from the cyanobacterial circadian system. In addition, very recent results indicate that mammals have a circadian clock that functions in the absence of transcription and translation. Nonetheless, our results on the first goal mentioned above continue to reinforce the importance of transcriptional regulation. For example, only a few fly genes have been shown to affect circadian timing when their dose is manipulated (1 gene instead of the normal 2; or 1 extra gene, 3 instead of 2), and these are all transcription factors.
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bioRxiv : the preprint server for biology (2024)
Dingbang Ma, Pranav Ojha,Albert D. Yu, Maisa S. Araujo,Weifei Luo, Evelyn Keefer,Madelen M. Díaz, Meilin Wu,William J. Joiner,Katharine C. Abruzzi,Michael Rosbash
Proceedings of the National Academy of Sciencesno. 15 (2024): e2321338121-e2321338121
Robert G. Roeder,Sara K. Deibler, Andrew D. Jacobson,James W. Lillie,Michael Rosbash,Robert H. Singer,Narendra Wajapeyee
Molecular Cellno. 13 (2023): 2152-2154
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biorxiv(2023)
biorxiv(2023)
Cellno. 13 (2023): 2722-2724
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