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个人简介
Dr. Porteus was raised in California and was a local graduate of Gunn High School before completing A.B. degree in “History and Science” at Harvard University where he graduated Magna Cum Laude and wrote an thesis entitled “Safe or Dangerous Chimeras: The recombinant DNA controversy as a conflict between differing socially constructed interpretations of recombinant DNA technology.” He then returned to the area and completed his combined MD, PhD at Stanford Medical School with his PhD focused on understanding the molecular basis of mammalian forebrain development with his PhD thesis entitled “Isolation and Characterization of TES-1/DLX-2: A Novel Homeobox Gene Expressed During Mammalian Forebrain Development.” After completion of his dual degree program, he was an intern and resident in Pediatrics at Boston Children’s Hospital and then completed his Pediatric Hematology/Oncology fellowship in the combined Boston Chidlren’s Hospital/Dana Farber Cancer Institute program. For his fellowship and post-doctoral research he worked with Dr. David Baltimore at MIT and CalTech where he began his studies in developing homologous recombination as a strategy to correct disease causing mutations in stem cells as definitive and curative therapy for children with genetic diseases of the blood, particularly sickle cell disease. Following his training with Dr. Baltimore, he took an independent faculty position at UT Southwestern in the Departments of Pediatrics and Biochemistry before again returning to Stanford in 2010 as an Associate Professor. During this time his work has been the first to demonstrate that gene correction could be achieved in human cells at frequencies that were high enough to potentially cure patients and is considered one of the pioneers and founders of the field of genome editing—a field that now encompasses thousands of labs and several new companies throughout the world. His research program continues to focus on developing genome editing by homologous recombination as curative therapy for children with genetic diseases but also has interests in the clonal dynamics of heterogeneous populations and the use of genome editing to better understand diseases that affect children including infant leukemias and genetic diseases that affect the muscle. Clinically, Dr. Porteus attends at the Lucille Packard Children’s Hospital where he takes care of pediatric patients undergoing hematopoietic stem cell transplantation.
研究兴趣
论文共 155 篇作者统计合作学者相似作者
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MOLECULAR THERAPY NUCLEIC ACIDSno. 1 (2024): 102134-102134
M. Cromer, Aadit Shah, Kiran Majeti, Freja Ekman,Sridhar Selvaraj,Eric Soupene, Prathamesh Chati,Roshani Sinha,Sofia Luna,Carsten Charlesworth, Travis McCreary,Benjamin Lesch,
crossref(2024)
Amanda M. Dudek, William N. Feist, Elena J. Sasu,Sofia E. Luna, Kaya Ben-Efraim,Rasmus O. Bak,Alma-Martina Cepika,Matthew H. Porteus
Cell Stem Cellno. 4 (2024): 499-518.e6
Sofia E. Luna,Joab Camarena,Jessica P. Hampton, Kiran R. Majeti,Carsten T. Charlesworth,Eric Soupene, Sridhar Selvaraj, Kun Jia,Vivien A. Sheehan,M. Kyle Cromer,Matthew H. Porteus
biorxiv(2024)
Simon N Chu,Eric Soupene,Beeke Wienert, Han Yin, Devesh Sharma, Travis McCreary, Kun Jia, Shota Homma,Jessica P Hampton,James M Gardner,Bruce R Conklin,Tippi C MacKenzie,
biorxiv(2024)
Alma-Martina Cepika,Laura Amaya, Colin Waichler, Mansi Narula, Michelle M Mantilla,Benjamin C Thomas, Pauline P Chen,Robert Arthur Freeborn,Mara Pavel-Dinu,Jason Nideffer,Matthew Porteus,Rosa Bacchetta,
bioRxiv : the preprint server for biology (2024)
Hana Y. Ghanim,Matthew H. Porteus
IMMUNOLOGICAL REVIEWSno. 1 (2024): 157-177
Jonas L. Fowler, Sherry Li Zheng, Alana Nguyen,Angela Chen,Xiaochen Xiong,Timothy Chai,Julie Y. Chen,Daiki Karigane,Allison M. Banuelos,Kouta Niizuma,Kensuke Kayamori,Toshinobu Nishimura,
Developmental Cell (2024)
Danielle A. Simmons,Sridhar Selvaraj, Tingshuo Chen, Gloria Cao, Talita Sauto Camelo,Tyne L.M. McHugh, Selena Gonzalez,Renata Martin, Juste Simanauskaite,Nobuko Uchida,Matthew Porteus,Frank M. Longo
crossref(2024)
Alice Bertaina,Rosa Bacchetta,David C. Shyr,Gopin Saini, Jennifer Lee,Karen Kristovich, Rajni Agarwal-Hashmi, Dr. Orly R. Klein,Kathryn Melsop, Keri Tate,Giulia Barbarito, Linda Oppizzi,
Transplantation and Cellular Therapyno. 2 (2024): S13
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