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There is increasing evidence to support the concept that the malignant behavior of some tumors is sustained by the deregulated activation of growth factor receptors. Our work in the past few years has uncovered an important regulator of invasive cell growth, the Met receptor tyrosine kinase. In normal cells, Met acts to relay signals from the cell surface that promote tissue organisation. However when these pathways are altered in cancer cells, this acts to enhance cell invasion the first step of metastasis.
Our aims are to identify what signal transduction pathways are important for the development of human cancers and how these can be targeted with drug therapies. This is a complex question that requires a full understanding of how signals are integrated in normal cells and how these signals become altered in tumor cells, in the context of other genetic alterations.
My lab has focused on and will continue to address these questions using the Met receptor tyrosine kinase and oncogene as a model. We will focus on signals required for anchorage independent growth, morphological cell transformation, epithelial mesenchymal transition, cell invasion and tumorigenesis.
Our aims are to identify what signal transduction pathways are important for the development of human cancers and how these can be targeted with drug therapies. This is a complex question that requires a full understanding of how signals are integrated in normal cells and how these signals become altered in tumor cells, in the context of other genetic alterations.
My lab has focused on and will continue to address these questions using the Met receptor tyrosine kinase and oncogene as a model. We will focus on signals required for anchorage independent growth, morphological cell transformation, epithelial mesenchymal transition, cell invasion and tumorigenesis.
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Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
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Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
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Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
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Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
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Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
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Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
crossref(2024)
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crossref(2024)
Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
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COLD SPRING HARBOR PERSPECTIVES IN MEDICINEno. 2 (2024): a041324-a041324
Xianbing Zhu,Zheng Fu, Kendall Dutchak,Azadeh Arabzadeh,Simon Milette,Jutta Steinberger,Geneviève Morin,Anie Monast,Virginie Pilon,Tim Kong, Bianca N. Adams, Erika Prando Munhoz,
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