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Dr. McQueen’s early scientific work was in the measurement of enzymes and isoenzymes in heart and liver disease and in the relationship of serum cholinesterase phenotypes with the response to the muscle relaxant succinylcholine. As a physician and Director of the Lipid Research Clinic, his clinical focus has been on lipid disorders, primary and secondary prevention of cardiovascular disease, and the investigation of statins, fibrates, and probucol in reducing disease risk. While continuing this work, he has expanded his clinical research laboratory to provide analytical support for the large epidemiologic studies and clinical trials from the Population Health Research Institute under the leadership of Dr. Salim Yusuf. The laboratory evaluates the role of lipids, inflammation, infection, hormones, and genes in multinational studies to identify clinical, nutritional, socioeconomic, and genetic factors underlying the development of cardiovascular disease, diabetes, and obesity. With the investigators in these studies, he has established a bank of several hundred thousand well-characterized patient samples, stored in liquid nitrogen. With current growth rates, this will increase to 2–3 million in the next 5 years. The tissue bank is the basis of a proposal from clinical and science departments at McMaster University, Hamilton Health Sciences, and St. Joseph’s Healthcare to establish a high-throughput proteomics facility to investigate population proteomics.
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JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASEno. 8 (2023): 335-335
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