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Dr. Masatsugu Hori MD, PhD.is currently the President of Osaka Medical Center for Cancer and Cardiovascular Diseases. He graduated Osaka University School of Medicine in 1970 and trained as a resident at Osaka University Hospital for three years. He worked at Albert Einstein College of Medicine, Yeshiva University in N.Y., USA as a Visiting Assistant Professor for two years (1979-1981) and engaged in the research work ondiastolic function of the heart. He was appointed as the chief of cardiology, Osaka University, School of Medicine in 1989, and Professor of Medicine, Osaka University in 1997.
He investigated the role of thromboembolism in small coronary arteries and found the coronary hyperemic response after coronary microsphere-embolization, attributable to endogenous adenosine release. He first investigated the nonreflow in patients with acute myocardial infarction by contrast echo technique. He observed the enhanced adenosine production in ischemic preconditioning due to increased activity of 5’-nucleotidase induced by PKC activation which affords cellular protection and improvement of coronary microcirculation. He also found that late ischemic preconditioning is attributable to enhanced Mn-SOD production. Recently, he investigated signal transduction in cardiac hypertrophy and elucidated the molecular mechanism of activation of HB-EGF and the signaling pathway in ASK-1 regulating hypertrophy and apoptosis.
In clinical research, he conducted a large registry study for acute coronary syndrome (OACIS) in which classic and genetic risk factors for ischemic heart disease were elucidated in Japanese population. He also conducted several clinical trials; β-blocker for chronic heart failure (MUCHA/J-CHF trials) and aspirin for atrial fibrillation (JAST trial), antithrombin inhibitor (dabigatran/RE-LY trial substudy) and Xa inhibitor (rivaroxaban, J -ROCKET AF) for non-valvular AF. It should be noted that he contributed to the initial set-up of cardiac transplantation in Japan.
He received several awards for his scientific achievements. He has served for major scientific societies as the board of directors. He has been for ten years the chair of the Scientific Committee in Japanese Circulation Society, and contributed to writing many clinical guidelines for cardiovascular diseases. He hosted several national international scientific meetings, e.g. the 73th Annual Scientific Meeting of the Japanese Circulation Society and the 104th Annual Meeting of Internal Medicine. Recently, he organized ISHR World Congress as a chair and president of the society. He also serves for the scientific board as a member of the Science Council of Japan. He published a total 520 papers in the international journals.
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AMERICAN HEART JOURNAL PLUS: CARDIOLOGY RESEARCH AND PRACTICE (2023): 100292-100292
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