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职业迁徙
个人简介
A major focus of his post-doctoral research was the post-transcriptional control of gene expression, where he showed that the HIV-1 Rev protein is a sequence-specific activator of unspliced viral RNA nucleocytoplasmic export – an essential prerequisite for subsequent viral protein expression and particle production.
His group became particularly interested in a hitherto obscure HIV-1 protein, Vif, a potent regulator of viral infectivity. Through classical cell-fusion experiments and studies undertaken in cells of different primate species, they proposed that Vif acts by suppressing an innate immune mechanism residing in human cells. A comparative transcriptomic strategy using cDNA subtraction led to the identification, in 2002, of the human protein APOBEC3G as an anti-viral protein specifically targeted by Vif. Subsequent work revealed that APOBEC3G inhibits HIV-1 infection by hypermutating viral cDNA by excessive cytidine deamination, and interfering with viral cDNA synthesis (i.e., reverse transcription), thus defining a novel mechanism of innate immunity.
The lab continues to work on the molecular pathogenesis of virus infections of importance to global health, particularly HIV-1 and influenza A virus and embraces a broad range of molecular genetic, cultured cell, biochemical, structural, bioinformatic and cohort-based methods to study fundamental principles of virus replication and host-mediated control.
Michael has delivered many named lectures, received an Elizabeth Glaser Pediatric AIDS Foundation Scientist Award in 2001 and was awarded the 2010 M Jeang Retrovirology Prize. He was elected as a Fellow of the Academy of Medical Sciences (FMedSci) in 2003, as a Member of the European Molecular Biology Organisation (EMBO) in 2005, and as a Fellow of the Royal Society (FRS) in 2007. He has served on numerous grant and fellowship review panels in the US and Europe is a Section Editor for the Open Access journal PLoS Pathogens, and an Editor for Virology.
研究兴趣
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PLOS PATHOGENSno. 11 (2023): e1011776-e1011776
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EClinicalMedicine (2023): 102086
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Joana Andrade,Edward J. Scourfield, S. Peswani-Sajnani,Kate Poulton, Tom ap Rees,Paniz Khooshemehri,George Doherty, Sim‐Heng Ong, Iulia Ivan, Navid Goudarzi, Iain Gardiner, Eric D. Caine,
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