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Martin Eilers is professor of biochemistry and molecular biology at the University of Würzburg in Germany. After a Ph.D. at the university of Basel, he joined Michael Bishop’s laboratory at the UCSF, where he started working on Myc by generating MycER chimeric molecules, which are widely used as tools to study Myc and N-Myc proteins. Since then, his work focuses on the function and regulation of human Myc proteins. One focus of his recent work is the question of how proteasomal turnover of Myc proteins is coupled to the transcriptional activities. His work on neuroblastoma started from gene expression studies that identified a gene expression profile associated with MYCN amplification. An shRNA screen of these genes identified Aurora-A as being essential for growth of MYCN-amplified cells. The subsequent molecular analysis showed that Aurora-A and N-Myc form a complex that stabilizes N-Myc. Importantly, the complex can be targeted using small molecule inhibitors, leading to degradation of N-Myc and also, for some inhibitors, Aurora-A. In his presentation, Martin will discuss new insights into the composition, the structure and the function of the Aurora-A/N-Myc and Aurora-A/c-Myc complexes and will discuss implications for a targeted therapy.
研究兴趣
论文共 345 篇作者统计合作学者相似作者
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SCIENCE IMMUNOLOGYno. 94 (2024): eadk0092-eadk0092
Abdallah Gaballa, Anneli Gebhardt-Wolf,Bastian Krenz, Greta Mattavelli,Mara John,Giacomo Cossa, Silvia Andreani,Christina Schülein-Völk, Francisco Montesinos, Raphael Vidal,Carolin Kastner,Carsten P. Ade,
Nature Communicationsno. 1 (2024): 1-18
Dimitrios Papadopoulos, Stefanie Anh Ha, Daniel Fleischhauer, Leonie Uhl, Timothy J. Russell,Ivan Mikicic, Katharina Schneider, Annika Brem, Omkar Rajendra Valanju,Giacomo Cossa,Peter Gallant,Christina Schuelein-Voelk,
Molecular Cell (2024)
Laura Grunewald,Lena Andersch,Konstantin Helmsauer,Silke Schwiebert,Anika Klaus,Anton G Henssen, Teresa Straka,Marco Lodrini, Sebastian G Wicha,Steffen Fuchs,Falk Hertwig,Frank Westermann,
biorxiv(2024)
Science Immunologyno. 94 (2024)
Victoria Mamontova,Barbara Trifault,Anne-Sophie Gribling-Burrer,Patrick Bohn, Pit Preckwinkel,Werner Schmitz, Peter Gallant,Dimitrios Papadopoulos,Martin Eilers,Tony Gutschner,Redmond P Smyth,Kaspar Burger
biorxiv(2024)
Luana D'Artista, Athina Anastasia Moschopoulou,Iros Barozzi, Amanda J Craig,Marco Seehawer, Lea Herrmann,Martina Minnich, Tae-Won Kang, Elke Rist,Melanie Henning,Sabrina Klotz, Florian Heinzmann,
Journal of hepatologyno. 1 (2023): 141-149
Xi Qiao,Ying Liu, Maria Llamazares Prada, Aravind K. Mohan,Abhishekh Gupta,Alok Jaiswal,Mukund Sharma, Joni Merisaari,Heidi M. Haikala, Kati Talvinen,Laxman Yetukuri,Joanna W. Pylvänäinen,
crossref(2023)
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