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Research Interests
Biochemistry, Chemical Biology, and Synthetic Biology — Designing new biosynthetic pathways for in vivo cellular production of biofuels and pharmaceuticals
Our research laboratory utilizes the approaches of mechanistic biochemistry, molecular and cell biology, metabolic engineering, and synthetic biology to address problems in energy and human health. We design and create new biosynthetic pathways in microbial hosts for in vivo production of biofuels from abundant crop feedstocks and pharmaceuticals from natural products or natural product scaffolds. A unifying theme of all of our projects is a focus on gaining a detailed molecular understanding of how living cells control enzymatic processes within the context of the entire metabolic network. Specific projects under current investigation include (i) the in vivo production of biofuels from plant biomass, and (ii) the development of new biosynthetic methods for selective, catalytic C-F bond formation under mild conditions.
Biochemistry, Chemical Biology, and Synthetic Biology — Designing new biosynthetic pathways for in vivo cellular production of biofuels and pharmaceuticals
Our research laboratory utilizes the approaches of mechanistic biochemistry, molecular and cell biology, metabolic engineering, and synthetic biology to address problems in energy and human health. We design and create new biosynthetic pathways in microbial hosts for in vivo production of biofuels from abundant crop feedstocks and pharmaceuticals from natural products or natural product scaffolds. A unifying theme of all of our projects is a focus on gaining a detailed molecular understanding of how living cells control enzymatic processes within the context of the entire metabolic network. Specific projects under current investigation include (i) the in vivo production of biofuels from plant biomass, and (ii) the development of new biosynthetic methods for selective, catalytic C-F bond formation under mild conditions.
研究兴趣
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biorxiv(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv : the preprint server for biology (2023)
bioRxiv : the preprint server for biologyno. 16 (2023): 2480-2491
Proceedings of the National Academy of Sciences of the United States of Americano. 12 (2023)
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