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RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease.
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FRONTIERS IN AGING NEUROSCIENCE (2024): 1346621-1346621
MOLECULAR NEUROBIOLOGYno. 6 (2023): 3044-3053
MOLECULAR NEUROBIOLOGY (2023)
Aileen M. Lynch, Sean Kilroy, Heather McKee,Fintan Sheerin,Monique Epstein, Ariane Girault,Pierre Gillois,Jean Luc Bosson,Carole Rolland,Mary Harkin, Ciarán McKinney,Gabrielle McKee
Social Science Research Network (2022)
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