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Research interests
My long-standing research interests have focused on the role and regulation of epithelial secretory proteins. This work has principally involved the study of the airway epithelium through 3D in vitro model systems. More recently, it has expanded to include the oral and nasal mucosa and the epithelium of the middle ear. My specific interests have focused on the fields of innate immunity, host defence and tumour biology.
I have also used my tissue culture expertise to develop in vitro models of human salivary glands from fresh human tissue. We are now routinely isolating cells from the human parotid, sublingual and submandibular glands, and adult and foetal tissue, and are characterising cell phenotype under different culture conditions. We are also using these models to study the tumourigenesis in salivary gland cancer by introducing novel fusion genes often found in these glandular tumours.
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Z Alharbi, L Bingle, C Bingle
03.02 - Airway cell biology and immunopathology (2022)
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Grace C Lin,Merima Smajlhodzic, Anna-Maria Bandian,Heinz-Peter Friedl,Tamara Leitgeb,Sabrina Oerter, Kerstin Stadler, Ulrich Giese,Johannes R Peham,Lynne Bingle,Winfried Neuhaus
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