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个人简介
The work of L. Scorrano has changed classical tenets in the fields of apoptosis and mitochondrial pathophysiology. His work on cristae remodeling paved the way for the new field of mitochondrial dynamics. In the following years, his lab discovered that Opa1 works as a molecular staple holding cristae junctions tight, deficient in dominant optic atrophy, targeted during apoptosis and essential in vivo to control tissue damage and even to correct mitochondrial diseases; identified the first molecular bridge between ER and mitochondria (starting the new field of interorganellar contact sites); showed that mitochondria change shape to control autophagy, or to produce progesterone during pregnancy; demonstrated that cristae shape dictates assembly of proteins and efficiency of respiration; discovered a novel pathway of Notch1 signaling controlled by mitochondrial fusion and Ca2+ essential during heart development; discovered that mitochondrial fusion mounts a metabolic defense against the intracellular parasite Toxoplasma.
研究兴趣
论文共 339 篇作者统计合作学者相似作者
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Ludovica Zambello,Luca Scorrano
Nature Metabolismno. 2 (2024): 198-199
Alice Lacombe,Luca Scorrano
Seminars in Cell & Developmental Biology (2024): 1-19
Elena Marchesan,Alice Nardin,Sofia Mauri,Greta Bernardo, Vivek Chander,Simone Di Paola,Monica Chinellato,Sophia von Stockum,Joy Chakraborty,Stephanie Herkenne, Valentina Basso,Emilie Schrepfer,
CELL DEATH AND DIFFERENTIATIONno. 2 (2024): 217-238
bioRxiv (Cold Spring Harbor Laboratory)no. 2 (2024): 217-238
CARDIOVASCULAR RESEARCHno. 18 (2024): 2917-2929
biorxiv(2024)
Martina Semenzato, Ludovica Zambello, Stefania Fumarola, Enrico Motta, Luana Piroli,Luca Scorrano,Camilla Bean
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Satoko Shinjo,Luca Scorrano
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