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The research focus of the Sumner lab includes the development of cutting-edge technologies for large-scale biochemical profiling of plant metabolites (ie metabolomics) and integrating these with other omics data. These technologies are then applied in a symbiotic manner for plant gene discovery, gene characterization and the elucidation of mechanistic responses to external stimuli; especially related to plant specialized metabolism or plant natural products biosynthesis. Technology enables the biology and the biology drives technology development. Current technology development projects include the development of a sophisticated and integrated ensemble including UHPLC-MS-SPE-NMR for the systematic and biologically driven annotation of plant metabolomes. This suite of tools is being applied to better understand carbon sequestration in cell wall lignin and lipids. The Sumner lab is also currently using integrated metabolomics for the discovery and characterization of triterpene saponin biosynthetic genes in the model legume Medicago truncatula. We have proven success in using this technology for a better understanding of natural products including flavonoids, isoflavonoids, terpenoids, and waxes.
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论文共 211 篇作者统计合作学者相似作者
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Goncalo Jorge Gouveia, Thomas Head,Leo L. Cheng,Chaevien S. Clendinen,John R. Cort,Xiuxia Du,Arthur S. Edison, Candace C. Fleischer,Jeffrey Hoch,Nathaniel Mercaldo,Wimal Pathmasiri,Daniel Raftery,
Matthew Pin, Ella F. Poynton, Tamara Jordan, Jonghyeok Kim, Benjamin Ledingham,Jeffrey A. van Santen,Vera Yang, Andrew Maras,Pegah Tavangar,Vasuk Gautam,Harrison Peters,Tanvir Sajed,
JOURNAL OF NATURAL PRODUCTSno. 11 (2023): 2554-2561
Scientific reportsno. 1 (2023): 18860-10
Mohamed Bayati, Hsin-Yeh Hsieh,Shu-Yu Hsu, Chenhui Li,Elizabeth Rogers, Anthony Belenchia,Sally A. Zemmer, Todd Blanc, Cindy LePage,Jessica Klutts,Melissa Reynolds,Elizabeth Semkiw,
WATER RESEARCH (2022): 118824-118824
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