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Peptides play many important physiological roles in most organisms. Neuropeptides and peptide hormones function in cell-cell signaling and are involved with a wide variety of biological functions including feeding and body weight regulation, fear, anxiety, pain, circadian rhythms, memory, reward mechanisms, and many others. We have discovered a number of novel peptides using mass spectrometry-based peptidomic techniques. Some of these are neuropeptides that function in cell-cell signaling that control feeding/body weight. Other novel peptides found in the peptidomic analyses are produced from cytosolic proteins, and some of these peptides are secreted and bind to extracellular receptors; these are termed “non-classical” neuropeptides, a novel class of cell-cell signaling molecule.In addition to peptides, we are also interested in enzymes that modify peptides/proteins. Our laboratory has discovered a dozen different carboxypeptidases and we are currently working towards determining their functions. One carboxypeptidase, which we named carboxypeptidase E (CPE), is responsible for the biosynthesis of most peptide hormones (such as insulin) and neuropeptides (such as enkephalin).
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Encyclopedia of Molecular Pharmacologypp.1288-1292, (2021)
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