基本信息
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职业迁徙
个人简介
Ph.D. 1970 University of California 。
Research Summary
The overall goal of research in this laboratory is to understand the mechanisms whereby neuronal precursors differentiate into mature functional neurons. To this end, we use the rat PC12 pheochromocytoma cell line developed in this laboratory as a model system to study the mechanism of action of nerve growth factor (NGF) and the steps that lead to neuronal differentiation. Among current projects in the laboratory are those addressing the following questions: 1) What is the essential property of the high-affinity NGF receptor that permits it to mediate the functional activities of NGF and how is this receptor different from the low-affinity, non-functional NGF receptor? 2) What is the transductional mechanism by which NGF receptor occupancy leads to subsequent response? 3) What are the steps beyond immediate transduction that lead to NGF mechanisms? 4) What is the mechanism by which NGF regulates growth cone motility? What are the molecules involved in this effect? 5) What genes are regulated by NGF? By what pathways are they regulated? 6) What are the mechanism by which NGF promotes the initiation and regeneration of neurites; specifically, what is the role of specific cytoskeleton proteins in this process? 7) How do NGF and other neuronotrophic substances maintain cell survival? 8) How do such agents regulate cell proliferation?
Honors and Awards
1965 B.S. with general and special honors
1975-1979 Sloan Foundation Fellowship in the Neurosciences
1981-1986 Career Development Award from the Irma T. Hirschl Trust
1986-1993 Javits Award (NIH-NINDS)
1987 Medal of Excellence for Contributions to Neuroscience Research CNR (Italy)
1994 Adele Blank Award for Research in Neurodegenerative Disease
2000 Dean's Distinguished Lecturer in Basic Sciences, Columbia University
Selected Publications
Specific downregulation of hippocampal ATF4 reveals a necessary role in synaptic plasticity and memory.
Pasini S, Corona C, Liu J, Greene LA, Shelanski ML.
Cell Rep. 2015 Apr 14;11(2):183-91.
Zoon's balanitis.
Hugh JM, Lesiak K, Greene LA, Pierson JC.
J Drugs Dermatol. 2014 Oct;13(10):1290-1.
Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models.
Aimé P, Sun X, Zareen N, Rao A, Berman Z, Volpicelli-Daley L, Bernd P, Crary JF, Levy OA, Greene LA.
J Neurosci. 2015 Jul 29;35(30):10731-49. doi: 10.1523/JNEUROSCI.0614-15.2015.
Tailoring CME with Chart Audits Linked to Individual Physician Performance to Improve Rheumatoid Arthritis Quality Measures.
Sapir T, Rusie E, Carter JD, Greene L, Moreo K.
J Contin Educ Health Prof. 2015 Apr;35 Suppl 1:S40-1. doi: 10.1002/chp.21285. No abstract available.
.
Impact of Quality Improvement Educational Interventions on Documented Adherence to Quality Measures for Adults with Crohn's Disease.
Greene L, Sapir T, Moreo K, Carter JD, Patel B, Higgins PD.
Inflamm Bowel Dis. 2015 May 27. [Epub ahead of print]
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Cancersno. 22 (2023): 5318-5318
Debarshi Banerjee, Shuobo Boboila, Shunpei Okochi,James M. Angelastro, Angela V. Kadenhe-Chiweshe,Gonzalo Lopez,Andrea Califano,Eileen P. Connolly,Lloyd A. Greene,Darrell J. Yamashiro
CANCER RESEARCH COMMUNICATIONSno. 12 (2023): 2518-2530
Cell death and differentiationno. 5 (2023): 1097-1154
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