Lishan Su
教授
Division of Virology
Pathogenesis and Cancer, Institute of Human Virology, School of Medicine, University of Maryland;Department of Pharmacology, School of Medicine, University of Maryland;Department of Microbiology & Immunology, School of Medicine, University of Maryland;Greenebaum Comprehensive Cancer Center, University of Maryland
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基本信息
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职业迁徙
个人简介
My research laboratory has focused on several areas of human immunology and virology, particularly in studying human immuno-pathology of chronic virus infections. My group was one of the first to use humanized mouse models to study HIV-1 infection and pathogenesis, and to develop human blood stem cell-based gene therapy for AIDS. My lab has identified novel virological and immunological mechanisms of HIV-1 and HBV pathogenesis. In recent years, my group has discovered and focused on the pDC-interferon-macrophage axis in the immuno-pathogenesis and therapy of chronic HIV & HBV infections. The group has also started investigation of the pDC-IFN-M2 axis in tumor microenvironments (TME) and in cancer immune therapy. After joining The Institute of Human Virology at UMSOM in Oct. 2020, we continue the research programs to use HIV and HBV viruses as probes to dissect human immunity and inflammatory diseases, and to develop antibody and cell-based drugs targeting novel immune cells and signaling pathways. The laboratory thus studies HIV-1 and HBV (Virology) and how their interactions with human innate immune cells cause inflammatory diseases (Immunology) using various cell and organoid cultures, as well as humanized mouse models. In addition, we are developing novel drugs including antibodies, CAR-T and therapeutic vaccines (Immunotherapy) to treat human inflammatory diseases including virus infection and cancer.
研究兴趣
论文共 216 篇作者统计合作学者相似作者
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Michelle Y. -H. Lee,Rohini Mopuri,Stacey Lapp, Amanda M. Metz, Vasanthi Govindu,Aaron D. Silva Trenkle,Kirti A. Karunakaran, Thang Ton,Gabriel A. Kwong,John D. Altman,Lishan Su,Rama R. Amara,
JOURNAL OF MEDICAL PRIMATOLOGYno. 5 (2023): 314-315
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Shadi Salloum, Raymond T. Chung, Volney Spalding, Brian A. Fellenstein, Andre Jeyarajan,Lishan Su, Nadia Alatrakchi, Wenyu Lin,Guangming Li
HEPATOLOGY (2023): S416-S417
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Journal of Immunologyno. 1 (2023): 235.21-235.21
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Journal of Immunologyno. 1 (2023): 233.10-233.10
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Journal of Immunologyno. 1 (2023): 141.11-141.11
Journal of Immunologyno. 1 (2023): 245.18-245.18
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Journal of medical virologyno. 7 (2023)
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