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In our work, the statistical physics of the jammed granular collecive and the living epithelial collective come together in a surprising way. We have shown that variation of shape from cell-to-cell within a homogeneous confluent epithelial tissue is not so much a matter of biological randomness as much as it is a physical necessity required for cellular migration, tissue development, and tissue remodeling.
We have demonstrated how across a vastly diverse array of collective epithelial systems, the physics of cell jamming exerts an overriding geometrical constraint upon underlying molecular events and their macroscopic expression.
We have demonstrated how across a vastly diverse array of collective epithelial systems, the physics of cell jamming exerts an overriding geometrical constraint upon underlying molecular events and their macroscopic expression.
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BIOPHYSICS REVIEWSno. 4 (2023): 041304-041304
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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