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The Linington lab is focused upon contemporary applications of marine natural products chemistry to biological problems. Within this general area we have specific interests in the development of new high-content screening technologies, the discovery and hit-to-lead development of lead scaffolds for drug development, and the determination of compound modes of action. The overall objectives of this research platform are the discovery of new compound classes for drug development against pathogenic bacteria, cancer, and global health parasites, and the creation of chemical probes to explore the basic biology of these target organisms.
To accomplish these objectives, the research program employs techniques spanning an array of disciplines including marine microbiology, natural products isolation and structure elucidation, bioassay design and development, synthetic medicinal chemistry, and 'omics' approaches to problems in biomedical research, including the development of new metabolomics tools for chemical and biological characterization of complex natural product libraries. This combination of techniques provides a mechanism for the examination of complex problems at the interface of chemistry and biology, using modern methods and analytical technologies to explore how natural products can contribute to our understanding of disease and disease treatment.
To accomplish these objectives, the research program employs techniques spanning an array of disciplines including marine microbiology, natural products isolation and structure elucidation, bioassay design and development, synthetic medicinal chemistry, and 'omics' approaches to problems in biomedical research, including the development of new metabolomics tools for chemical and biological characterization of complex natural product libraries. This combination of techniques provides a mechanism for the examination of complex problems at the interface of chemistry and biology, using modern methods and analytical technologies to explore how natural products can contribute to our understanding of disease and disease treatment.
研究兴趣
论文共 148 篇作者统计合作学者相似作者
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Claire H. Fergusson, Julia Saulog, Bruno S. Paulo,Darryl M. Wilson,Dennis Y. Liu, Nicholas J. Morehouse,Samantha Waterworth, John Barkei, Christopher A. Gray,Jason C. Kwan, Alessandra S. Eustaquio,Roger G. Linington
crossref(2024)
BMC Bioinformaticsno. 1 (2024): 1-21
Claire H. Fergusson, Julia Saulog, Bruno S. Paulo,Darryl M. Wilson,Dennis Y. Liu, Nicholas J. Morehouse,Samantha Waterworth, John Barkei, Christopher A. Gray,Jason C. Kwan,Alessandra S. Eustaquio,Roger G. Linington
Chemical Science (2024)
Sean B Romanowski,Sanghoon Lee,Sylvia Kunakom, Bruno S Paulo,Michael J J Recchia,Dennis Y Liu,Hannah Cavanagh,Roger G Linington,Alessandra S Eustáquio
Proceedings of the National Academy of Sciences of the United States of Americano. 42 (2023)
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Journal of Agricultural and Food Chemistryno. 19 (2023): 7604-7617
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Thomas O. Metz,Joshua N. Adkins, Peter B. Armentrout, Patrick Chain, Fanny Chu,Courtney D Corley,John R. Cort,Elizabeth Denis,Daniel Drell,Katherine R. Duncan,Robert G. Ewing,Facundo M. Fernandez,
arxiv(2023)
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Analytical chemistryno. 32 (2023): 11908-11917
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