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Bio
My primary focus is on understanding the complex roles of astrocytes in the brain. Astrocytes are a type of glial cell that play crucial roles in maintaining brain homeostasis, supporting neuron function, and responding to injury. My work has particularly centered on a subtype of reactive astrocytes that we discovered, which release toxic factors capable of killing specific neurons.
This discovery has significant implications for neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis. By studying how these reactive astrocytes contribute to neuroinflammation and neurodegeneration, we aim to uncover the underlying mechanisms that drive these diseases. Our goal is to identify potential therapeutic strategies that can mitigate the harmful effects of these astrocytes, thereby slowing or even halting the progression of neurodegenerative conditions.
Through our research, we hope to pave the way for new treatments that can improve the quality of life for individuals affected by these debilitating diseases. Our ongoing studies continue to explore the intricate interactions between astrocytes and neurons, striving to unlock the mysteries of the brain and develop innovative approaches to combat neurological disorders.
This discovery has significant implications for neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis. By studying how these reactive astrocytes contribute to neuroinflammation and neurodegeneration, we aim to uncover the underlying mechanisms that drive these diseases. Our goal is to identify potential therapeutic strategies that can mitigate the harmful effects of these astrocytes, thereby slowing or even halting the progression of neurodegenerative conditions.
Through our research, we hope to pave the way for new treatments that can improve the quality of life for individuals affected by these debilitating diseases. Our ongoing studies continue to explore the intricate interactions between astrocytes and neurons, striving to unlock the mysteries of the brain and develop innovative approaches to combat neurological disorders.
Research Interests
Papers共 146 篇Author StatisticsCo-AuthorSimilar Experts
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Holly K. Gildea,Shane A. Liddelow
Molecular Neurodegenerationno. 1 (2025): 1-14
Melissa L Cooper, Holly K Gildea, Maria Clara Selles, Eleni Katafygiotou,Shane A Liddelow,Moses V Chao
Proceedings of the National Academy of Sciences of the United States of Americano. 11 (2025): e2418249122-e2418249122
Michael R O'Dea,Shane A Liddelow
biorxiv(2025)
Philip Hasel,Melissa L Cooper,Anne E Marchildon,Uriel Rufen-Blanchette,Rachel D Kim,Thong C Ma,Adam M R Groh,Emily J Hill, Eleanor M Lewis,Michał Januszewski, Sarah E W Light, Cody J Smith, Jo Anne Stratton, Steven A Sloan,Un Jung Kang,Moses V Chao,Shane A Liddelow
Cell reportsno. 3 (2025): 115344-115344
Anna C Geraghty, Lehi Acosta-Alvarez, Maria C Rotiroti, Selena Dutton, Michael R O'Dea, Wonju Kim, Vrunda Trivedi, Rebecca Mancusi, Kiarash Shamardani,Karen Malacon,Pamelyn J Woo, Naiara Martinez-Velez, Theresa Pham, Noemi N Reche-Ley, Gabriel Otubu, Enrique H Castenada, Kamsi Nwangwu, Haojun Xu, Sara B Mulinyawe, Daniel B Zamler,Lijun Ni, Kevin Cross,Justin Rustenhoven,Jonathan Kipnis,Shane A Liddelow, Crystal L Mackall, Robbie G Majzner,Michelle Monje
Cellno. 12 (2025): 3238-3258.e25
Igor Adameyko,Trygve Bakken,Aparna Bhaduri,Chintan Chhatbar,Mariella G Filbin,David Gate,Hannah Hochgerner, Chang Nam Kim,Jordan Krull,Gioele La Manno,Qingyun Li,Sten Linnarsson,Qin Ma,Christian Mayer,Vilas Menon, Patricia Nano,Marco Prinz,Steve Quake,Christopher A Walsh, Jin Yang,Omer Ali Bayraktar,Ozgun Gokce,Naomi Habib,Genevieve Konopka,Shane A Liddelow,Tomasz J Nowakowski
Nature neuroscienceno. 12 (2024): 2278-2291
Michael T Heneka,Wiesje M van der Flier,Frank Jessen, Jeroen Hoozemanns,Dietmar Rudolf Thal,Delphine Boche,Frederic Brosseron,Charlotte Teunissen,Henrik Zetterberg,Andreas H Jacobs,Paul Edison,Alfredo Ramirez,Carlos Cruchaga,Jean-Charles Lambert,Agustin Ruiz Laza, Jose Vicente Sanchez-Mut,Andre Fischer,Sergio Castro-Gomez,Thor D Stein,Luca Kleineidam,Michael Wagner,Jonas J Neher,Colm Cunningham,Sim K Singhrao,Marco Prinz,Christopher K Glass,Johannes C M Schlachetzki,Oleg Butovsky,Kilian Kleemann, Philip L De Jaeger,Hannah Scheiblich,Guy C Brown,Gary Landreth,Miguel Moutinho,Jaime Grutzendler,Diego Gomez-Nicola,Róisín M McManus,Katrin Andreasson,Christina Ising, Deniz Karabag,Darren J Baker,Shane A Liddelow,Alexei Verkhratsky,Malu Tansey,Alon Monsonego,Ludwig Aigner,Guillaume Dorothée,Klaus-Armin Nave,Mikael Simons,Gabriela Constantin,Neta Rosenzweig,Alberto Pascual,Gabor C Petzold,Jonathan Kipnis,Carmen Venegas,Marco Colonna,Jochen Walter,Andrea J Tenner,M Kerry O'Banion,Joern R Steinert,Douglas L Feinstein,Magdalena Sastre,Kiran Bhaskar,Soyon Hong,Dorothy P Schafer,Todd Golde,Richard M Ransohoff,David Morgan,John Breitner,Renzo Mancuso, Sean-Patrick Riechers
Nature reviews Immunologyno. 5 (2024): 321-352
Courtney M Kloske,Simin Mahinrad,Christopher J Barnum,Andre F Batista,Elizabeth M Bradshaw,Brittany Butts,Maria C Carrillo, Paramita Chakrabarty, Xiaoying Chen, Suzanne Craft,Sandro Da Mesquita, Luke C Dabin,Davangere Devanand,Violeta Duran-Laforet,Wassim Elyaman,Elizabeth E Evans,Patricia Fitzgerald-Bocarsly,Kate E Foley,Ashley S Harms,Michael T Heneka,Soyon Hong, Yu-Wen A Huang,Stephanie Jackvony,Laijun Lai,Yann Le Guen,Cynthia A Lemere,Shane A Liddelow,Alfonso Martin-Peña,Anna G Orr, Francisco J Quintana, Grace D Ramey,Jessica E Rexach, Stacey J S Rizzo,Claire Sexton, Alice S Tang, Jose G Torrellas, Andy P Tsai,Lynn van Olst, Keenan A Walker,Whitney Wharton,Malú Gámez Tansey,Donna M Wilcock
Alzheimer's & dementia the journal of the Alzheimer's Associationno. 1 (2024): e14291-e14291
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Author Statistics
#Papers: 146
#Citation: 25660
H-Index: 45
G-Index: 93
Sociability: 7
Diversity: 3
Activity: 177
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