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职业迁徙
个人简介
Natural killer (NK) cells are a type of white blood cell that provides protection against microbial pathogens and tumors. Since the early 1980’s, our lab has investigated how NK cells distinguish between normal healthy cells and cells that are transformed or infected with viruses. NK cells express a diverse array of inhibitory and activating receptors on their cells surface that bind to ligands expressed on the cell surface of potential target cells. When encountering healthy cells, signals transmitted by inhibitory NK receptors dominate and prevent autoimmunity, whereas the loss of ligands for the inhibitory receptors or the upregulation of ligands for the activating NK receptors on infected or transformed cells allows NK cells to kill these abnormal cells and secrete cytokine that influence the subsequent response by T cells and B cells. We have developed mouse models systems in which key signaling molecules such as DAP10 and DAP12 have been ablated to explore the physiological role of these NK receptors in resistance to viral infections (cytomegalovirus, poxviruses, and influenza) and primary tumorigenesis.
研究兴趣
论文共 804 篇作者统计合作学者相似作者
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Sujit Silas Armstrong,Daniel G. Chen, Sunil Kumar, James R. Heath,Matthew Feinstein,John R. Greenland,Daniel R. Calabrese,Lewis L. Lanier,Klaus Ley,Avishai Shemesh
biorxiv(2024)
Cancer Immunology Researchpp.OF1-OF17, (2024)
Oscar A Aguilar, Anita E Qualls, Maria D R Gonzalez-Hinojosa, Sarah Obeidalla,V Eric Kerchberger,Tasha Tsao,Jonathan P Singer,Mark R Looney,Wilfred Raymond,Steven R Hays,Jeffrey A Golden,Jasleen Kukreja,
American journal of respiratory and critical care medicineno. 1 (2024): 70-82
Xiaomeng Hu,Kathy White, Ari G. Olroyd, Rowena DeJesus, Antonia A. Dominguez,William E. Dowdle, Annabelle M. Friera,Chi Young, Frank Wells,Elaine Y. Chu, Cade Ellis Ito, Harini Krishnapura,
Eric Vivier, Lucas REBUFFET,Janine Melsen, Daniela Basurto-Lozada,Avinash Bhandoola,Niklas Björkström,Yenan Bryceson,Roberta Castriconi,Frank Cichocki,Marco Colonna,Daniel Davis,Andreas Diefenbach,
crossref(2024)
Daniel G. Chen,Jingyi Xie, Jongchan Choi,Rachel H. Ng,Rongyu Zhang, Sarah Li, Rick Edmark,Hong Zheng, Ben Solomon,Katie M. Campbell,Egmidio Medina,Antoni Ribas,
Cell Reportsno. 3 (2024): 113872-113872
Nature immunologyno. 4 (2023): 612-624
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