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Membrane signaling proteins provide the molecular basis for many neurological functions and the pathophysiology of many neurological and neuropsychiatric diseases. However, it remains a major challenge to fully elucidate the dynamic molecular processes of their assembly and function and to interpret those properties in the context of cellular, synaptic, circuit, and behavioral function. G protein-coupled receptors (GPCRs), which serve as the largest family of drug targets in biology, provide a particular challenge because of their complex activation and signaling properties, expression patterns, and diverse roles in neurophysiology and behavior. The Levitz lab uses high-resolution optical and chemical methods, including development of chemical optogenetic tools and single molecule fluorescence-based assays, to elucidate the fundamental biophysical processes that drive receptor function and to gain a deeper understanding of the role of individual receptors and downstream effectors in synapse function and disease.
研究兴趣
论文共 81 篇作者统计合作学者相似作者
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Benjamin J. Polacco,Braden T. Lobingier,Emily E. Blythe,Nohely Abreu, Prachi Khare, Matthew K. Howard, Alberto J. Gonzalez-Hernandez,Jiewei Xu,Qiongyu Li, Brandon Novy,Zun Zar Chi Naing,Brian K. Shoichet,
Nature Chemical Biologypp.1-11, (2024)
The Journal of biological chemistryno. 2 (2024): 105649-105649
Hermany Munguba,Vanessa A Gutzeit, Ipsit Srivastava, Melanie Kristt,Ashna Singh, Akshara Vijay, Anisul Arefin,Sonal Thukral,Johannes Broichhagen, Joseph M Stujenske,Conor Liston,Joshua Levitz
bioRxiv : the preprint server for biology (2024)
Gabriele Ciceri,Arianna Baggiolini, Hyein S. Cho,Meghana Kshirsagar, Silvia Benito-Kwiecinski,Ryan M. Walsh,Kelly A. Aromolaran, Alberto J. Gonzalez-Hernandez,Hermany Munguba,So Yeon Koo, Nan Xu, Kaylin J. Sevilla,
Natureno. 8000 (2024): 881-890
bioRxiv : the preprint server for biologyno. 1 (2024): 47-59.e7
Arlene Martinez-Rivera,Robert Fetcho, Lizzie Birmingham, Jin X Jiu,Ruirong Yang, Careen Foord, Diego Scala-Chavez, Narmin Mekawy,Kristen E Pleil,Virginia M Pickel,Conor Liston,Carlos M Castorena,
crossref(2024)
STRUCTUREno. 1 (2024): 47-59.e7
Nature biotechnologypp.1-11, (2024)
Nature Communicationsno. 1 (2023): 1-12
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bioRxiv : the preprint server for biology (2023)
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