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个人简介
Leonid Mirny combines biophysical modeling with analysis of large genomics data to address fundamental problems in biology. Mirny aims to understand how long DNA molecules of chromosomes are folded in 3D, and how this 3D organization is used by living cells. The Mirny group has proposed that DNA is folded by molecular motors that perform “loop extrusion”. The loop extrusion hypothesis has been confirmed experimentally and has revolutionized our understanding of chromosomes across all organisms. Now Mirny aims to understand how cells use this and other physical mechanisms to regulate its genes, repair DNA, and maintain epigenetic memory.
研究兴趣
论文共 255 篇作者统计合作学者相似作者
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Andrea Scelfo,Viviana Barra,Nezar Abdennur,George Spracklin, Florence Busato,Catalina Salinas-Luypaert, Elena Bonaiti,Guillaume Velasco,Frederic Bonhomme, Anna Chipont,Andrea E. Tijhuis,Diana C. J. Spierings,
JOURNAL OF CELL BIOLOGYno. 4 (2024)
Erica M. Hildebrand,Kirill Polovnikov,Bastiaan Dekker,Yu Liu, Denis L. Lafontaine,A. Nicole Fox, Ying Li,Sergey V. Venev,Leonid A. Mirny,Job Dekker
Molecular Cellno. 8 (2024): 1422-1441.e14
bioRxiv : the preprint server for biology (2024)
The Journal of cell biologyno. 4 (2024)
PHYSICAL REVIEW Xno. 4 (2023): 041029
Christopher D. McFarland,Julia A. Yaglom,Jonathan W. Wojtkowiak,Jacob G. Scott,David L. Morse,Michael Y. Sherman,Leonid A. Mirny
crossref(2023)
J Gil, L F Rosin, E Navarrete, N Chowdhury, S Abraham, G Cornilleau, E P Lei, J Mozziconacci,L A Mirny, H Muller,I A Drinnenberg
bioRxiv : the preprint server for biology (2023)
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Nature Structural & Molecular Biologyno. 10 (2023): 1582-1591
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José Pedro Gil,Leah F. Rosin, Emily Navarrete,Neil Chowdhury,Sameer Abraham,Gaétan Cornilleau,Elissa P. Lei,Julien Mozziconacci,Leonid A. Mirny,Héloïse Muller,Ines A. Drinnenberg
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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