基本信息
浏览量:0
职业迁徙
个人简介
Our ongoing scientific interests include investigations of signaling perturbations in the oncogenic PI3-kinase pathway, specifically the function and aberrations of the tumor suppressor PTEN in the context of leukemogenesis. We are currently investigating post-translational mechanisms of PTEN regulation and control of PTEN expression by microRNA.
We have recently identified a novel post-transcriptional mechanism of gene regulation of PTEN mediated through competitive interaction of cellular RNA molecules. These finding have opened a new field of study which embraces the notion that all cellular RNA molecules (coding and non-coding) have the ability to compete for microRNA binding and thereby mediate their relative functions, in trans. Future studies include functional analyses of the non-coding transcriptome, its aberrant regulation, and the consequences for human disease and cancer therapy.
Finally, working closely with the Leukemia group at the Princess Margaret Cancer Centre, we are intensely investigating the genetic alterations and molecular mechanisms that underlie the pathogenesis of human leukemias, with the aim of identifying cellular mechanisms of chemotherapy resistance, new therapeutic targets and novel strategies for disease prevention.
We have recently identified a novel post-transcriptional mechanism of gene regulation of PTEN mediated through competitive interaction of cellular RNA molecules. These finding have opened a new field of study which embraces the notion that all cellular RNA molecules (coding and non-coding) have the ability to compete for microRNA binding and thereby mediate their relative functions, in trans. Future studies include functional analyses of the non-coding transcriptome, its aberrant regulation, and the consequences for human disease and cancer therapy.
Finally, working closely with the Leukemia group at the Princess Margaret Cancer Centre, we are intensely investigating the genetic alterations and molecular mechanisms that underlie the pathogenesis of human leukemias, with the aim of identifying cellular mechanisms of chemotherapy resistance, new therapeutic targets and novel strategies for disease prevention.
研究兴趣
论文共 121 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyno. 2 (2024): 298-305
Rachael Pettapiece-Phillips,Max Kotlyar, Rania Chehade,Leonardo Salmena,Steven A. Narod,Mohammad Akbari,Igor Jurisica,Joanne Kotsopoulos
crossref(2023)
Chen Li Chew,Andrea Lunardi,Federico Gulluni, Daniel T. Ruan,Ming Chen,Leonardo Salmena,Michiya Nishino,Antonella Papa,Christopher Ng, Jacqueline Fung,John G. Clohessy,Junko Sasaki,
crossref(2023)
Victoria Chan, Leslie Bone,Karen E. Anderson,Kai Zhang,Laura Orofiamma, Yasmin Awadeh, Daniel K.C. Lee,Norman J. Fu, Jonathan T.S. Chow,Leonardo Salmena,Len R. Stephens,Phillip T Hawkins,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Shana J. Kim,Tasnim Zaman, Aleksandra Uzelac,Ping Sun,Jan Lubinski,Steven A. Narod,Leonardo Salmena,Joanne Kotsopoulos
Cancer Prevention Researchno. 1_Supplement (2023): P036-P036
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn