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个人简介
Dr. Zon is internationally recognized for his pioneering work in the fields of stem cell biology and cancer genetics. He has been the pre-eminent figure in establishing the zebrafish as an invaluable genetic model for the study of the blood and hematopoietic development. The laboratory focuses on the developmental biology of hematopoiesis and cancer. They have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. They also have undertaken chemical genetic approach to blood development and have found that prostaglandins upregulates blood stem cells. This has led to a clinical trial to improve engraftment for patients receiving cord blood transplants. They recently developed suppressor screening genetics and found that transcriptional elongation regulates blood cell fate.
研究兴趣
论文共 762 篇作者统计合作学者相似作者
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David M Langenau, Matthew D Keefe, Narie Y Storer, Jeffrey R Guyon, Jeffery L Kutok,Xiuning Le,Wolfram Goessling,Donna S Neuberg,Louis M Kunkel,Leonard I Zon
Genes & developmentno. 5-6 (2024): 289-289
EXPERIMENTAL HEMATOLOGY (2023): S48-S48
Developmental Dynamicsno. 7 (2023): 1046-1060
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Valerie S LeBleu,Jianli Dai,Susan Tsutakawa, Brian A MacDonald,Joseph L Alge,Malin Sund, Liang Xie,Hikaru Sugimoto,John Tainer,Leonard I Zon,Raghu Kalluri
Developmental dynamics : an official publication of the American Association of Anatomists (2023)
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Silja Heilmann, Kajan Ratnakumar, Erin M. Langdon, Emily R. Kansler, Isabella S. Kim,Nathaniel R. Campbell, Elizabeth B. Perry, Amy J. McMahon,Charles K. Kaufman,Ellen van Rooijen,William Lee,Christine A. Iacobuzio-Donahue,
crossref(2023)
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