基本信息
浏览量:32
职业迁徙
个人简介
Antiretroviral treatment in pregnancy has improved maternal health and dramatically reduced the rate of vertical HIV transmission. Over one million pregnant women take these medications annually. Yet, a public health challenge remains, identifying the safest antiretrovirals to optimize maternal-child health outcomes, while continuing to achieve high efficacy in preventing vertical HIV transmission. While antiretrovirals are essential for maternal health and preventing HIV transmission to the infant, antiretrovirals have been associated with increased risk for adverse birth outcomes including preterm and small for gestation age births. The mechanisms underlying these outcomes remain poorly understood.
With the overall objective of optimizing antiretroviral therapy for pregnant women with HIV and their infants, the aims of the Serghides Lab are: (1) to identify mechanisms that contribute to adverse birth outcomes in the context of HIV and antiretroviral exposure, as well as identify biomarkers of risk, and interventions to improve outcomes, (2) to understand the effects of in utero exposure to HIV and antiretrovirals on the development of children who are HIV exposed but uninfected and identify underlying mechanisms, and (3) to develop animal and ex vivo models to facilitate the study of HIV and antiretroviral effects in the context of pregnancy.
With the overall objective of optimizing antiretroviral therapy for pregnant women with HIV and their infants, the aims of the Serghides Lab are: (1) to identify mechanisms that contribute to adverse birth outcomes in the context of HIV and antiretroviral exposure, as well as identify biomarkers of risk, and interventions to improve outcomes, (2) to understand the effects of in utero exposure to HIV and antiretrovirals on the development of children who are HIV exposed but uninfected and identify underlying mechanisms, and (3) to develop animal and ex vivo models to facilitate the study of HIV and antiretroviral effects in the context of pregnancy.
研究兴趣
论文共 117 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Rosauro Varo,Valerie M. Crowley, Humberto Mucasse,Antonio Sitoe, Justina Bramugy,Lena Serghides,Andrea M. Weckman,Clara Erice,Rubao Bila,Pio Vitorino, Campos Mucasse,Marta Valente,
International Journal of Infectious Diseases (2024): 34-40
Shreya H Dhume,Kayode Balogun, Ambalika Sarkar,Sebastian Acosta, Howard T J Mount,Lindsay S Cahill, John G Sled,Lena Serghides
Frontiers in molecular neuroscience (2024): 1376681-1376681
HEALTH & SOCIAL CARE IN THE COMMUNITY (2023): 1-10
引用0浏览0引用
0
0
Journal of the International Neuropsychological Societyno. s1 (2023): 55-56
引用0浏览0引用
0
0
Haneesha Mohan, Jessica Nguyen, Ben MacKenzie, Audrey Yee, Evelyn Yukino Laurette,Tanvi Sanghvi,Oscar Tejada,Valeriya Dontsova,Kit-Yi Leung,Cameron Goddard, Taylor De Young,John G. Sled,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn